{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:24:41Z","timestamp":1791296681603,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2-3","license":[{"start":{"date-parts":[[2007,7,16]],"date-time":"2007-07-16T00:00:00Z","timestamp":1184544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human chronic Chagas disease cardiomyopathy (CCC) is an inflammatory\u2010dilated cardiomyopathy occurring years after infection by the protozoan <jats:italic>Trypanosoma cruzi<\/jats:italic>. The heart inflammatory infiltrate in CCC shows a 2:1 predominance of CD8<jats:sup>+<\/jats:sup> in relation to CD4<jats:sup>+<\/jats:sup> T cells, with a typical Th1\u2010type cytokine profile. However, <jats:italic>in vitro<\/jats:italic> expansion of infiltrating T cells from heart biopsy\u2010derived fragments with interleukin\u20102 (IL\u20102) and phytohaemagglutinin leads to the outgrowth of CD4<jats:sup>+<\/jats:sup> over CD8<jats:sup>+<\/jats:sup> T cells. We hypothesized that survival cytokines, such as IL\u20102, IL\u20107 and IL\u201015 might be differentially involved in the growth and maintenance of heart\u2010infiltrating and peripheral CD8<jats:sup>+<\/jats:sup> T cells from CCC patients. We found that IL\u20107 and IL\u201015 were superior to IL\u20102 in the expansion and viability of CD8<jats:sup>+<\/jats:sup> T cells from both PBMC and heart\u2010infiltrating T\u2010cell lines from CCC patients, and the combination of the three cytokines showed synergic effects. Heart\u2010infiltrating CD8<jats:sup>+<\/jats:sup> T cells showed higher expression of both IL\u201015R\u03b1 and <jats:bold>\u03b3<\/jats:bold><jats:sub><jats:bold>c<\/jats:bold><\/jats:sub> chain than CD4<jats:sup>+<\/jats:sup> T cells, which may explain the improvement of CD8<jats:sup>+<\/jats:sup> T\u2010cell growth in the presence of IL\u20102\u2003+\u2003IL\u20107\u2003+\u2003IL\u201015. Immunohistochemical identification of IL\u201015 and the higher mRNA expression of IL\u201015R\u03b1, IL\u20107 and <jats:bold>\u03b3<\/jats:bold><jats:sub><jats:bold>c<\/jats:bold><\/jats:sub> chain in CCC heart tissues compared with control individuals indicate <jats:italic>in situ<\/jats:italic> production of survival cytokines and their receptors in CCC hearts. Together, our results suggest that local production of IL\u20107 and IL\u201015 may be associated with the maintenance and predominance of CD8<jats:sup>+<\/jats:sup> T cells, the cells effecting tissue damage in CCC hearts.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2007.01987.x","type":"journal-article","created":{"date-parts":[[2007,7,16]],"date-time":"2007-07-16T11:48:39Z","timestamp":1184586519000},"page":"362-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Locally Produced Survival Cytokines IL\u201015 and IL\u20107 may be Associated to the Predominance of CD8<sup>+<\/sup> T cells at Heart Lesions of Human Chronic Chagas Disease Cardiomyopathy"],"prefix":"10.1111","volume":"66","author":[{"given":"S. G.","family":"Fonseca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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