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In this study, we investigated whether genomic DNA derived from <jats:italic>Mycobacterium bovis<\/jats:italic> bacillus Calmette\u2013Guerin (BCG\u2010DNA) could be used as an effective adjuvant to enhance the immunogenicity and the protective capacity of recombinant cC1 antigen (rcC1) against pig cysticercosis. Pigs were vaccinated with rcC1 plus CpG\u2010containing DNA adjuvants (BCG\u2010DNA or CpG\u2010ODN) or rcC1 alone. Immunization with rcC1 alone induced a Th1\u2010biased response, whereas coadministration of rcC1 with BCG\u2010DNA or CpG\u2010ODN increased levels of IgG2, IFN\u2010\u03b3, percentage of CD8<jats:sup>+<\/jats:sup> and specific proliferation of peripheral blood mononuclear cells. Four weeks after the last immunization, pigs were infected with <jats:italic>Taenia solium<\/jats:italic> eggs. A high level of protection (81%) was induced by rcC1 immunization that was not significantly increased by the CpG\u2010containing DNA. These data indicate that coadministration of rcC1 plus BCG\u2010DNA or CpG\u2010ODN significantly enhanced Th1 response but did not improve the level of the protection induced.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2007.02013.x","type":"journal-article","created":{"date-parts":[[2007,11,17]],"date-time":"2007-11-17T06:37:46Z","timestamp":1195281466000},"page":"619-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Adjuvant Effects of Bacillus Calmette\u2013Guerin DNA or CpG\u2010oligonucleotide in the Immune Response to <i>Taenia solium<\/i> Cysticercosis Vaccine in 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