{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:09:15Z","timestamp":1769162955152,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,4,4]],"date-time":"2008-04-04T00:00:00Z","timestamp":1207267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>RUTI is a vaccine consisting of <jats:italic>Mycobacterium tuberculosis<\/jats:italic> bacilli grown in stress conditions that is fragmented, detoxified and liposomed. RUTI was designed to shorten the treatment of latent tuberculosis infection (LTBI) with isoniazid from 9\u2003months to just 1\u2003month, by additional treatment with two inoculations of RUTI 4\u2003weeks apart. During the validation process for monitoring the immunogenicity of administration of RUTI in a Phase I clinical trial, the question arose whether to introduce the tuberculin skin test (TST) in the screening of non\u2010LTBI volunteers. This study was designed to evaluate the effect of TST on subsequent different T\u2010cell interferon\u2010gamma release assay (TIGRA) responses, using a spectrum of <jats:italic>M. tuberculosis<\/jats:italic>\u2010related antigens (ESAT\u20106, CFP\u201010, 16\u2003kDa, 19\u2003kDa, MPT64, Ag 85B, 38\u2003kDa, hsp65, PPD and BCG). The results showed an increase in post\u2010TST response even in non\u2010LTBI subjects for most antigens tested, as measured both by whole blood assay (WBA) and ELISPOT. Increased ELISPOT response decreased toward pre\u2010TST levels within 1\u2003month whereas the WBA response did not. Taking into account that there is no definitive correlation between TST and TIGRA tests to diagnose LTBI and the feasibility that TST might alter the immune monitoring included in clinical trials, these data suggest that TST determination should be carefully planned to avoid any interference with TIGRA.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2008.02103.x","type":"journal-article","created":{"date-parts":[[2008,4,4]],"date-time":"2008-04-04T11:12:29Z","timestamp":1207307549000},"page":"610-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Tuberculin Skin Test Increases the Responses Measured by T Cell Interferon\u2010Gamma Release Assays"],"prefix":"10.1111","volume":"67","author":[{"given":"C.","family":"Vilaplana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ruiz\u2010Manzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Gil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cuchillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Montan\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Spallek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Ausina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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