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We show here that pH\u2010sensitive PE\/CHEMS liposomes can be used as a vehicle to efficiently deliver intact proteins for presentation by MHC class I. Mice immunized with listerial proteins encapsulated in such liposomes launched a strong CTL response and were protected against a subsequent challenge with <jats:italic>L. monocytogenes<\/jats:italic>. Remarkably, the CTL response was induced independently of detectable CD4<jats:sup>+<\/jats:sup> T cell help.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2008.02112.x","type":"journal-article","created":{"date-parts":[[2008,4,22]],"date-time":"2008-04-22T00:57:49Z","timestamp":1208825869000},"page":"594-602","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Liposome\u2010Encapsulated Antigens Induce a Protective CTL Response against <i>Listeria monocytogenes<\/i> Independent of CD4<sup>+<\/sup> T Cell Help"],"prefix":"10.1111","volume":"67","author":[{"given":"R.","family":"Grenningloh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Darj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zur Lage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.4.1458"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80465-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.6.2209"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1997.tb01002.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.9.3987"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0398-328"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.4049\/jimmunol.160.9.4449","article-title":"Enhancement of tumor outgrowth through CTL tolerization after peptide vaccination is avoided by peptide presentation on dendritic cells","volume":"160","author":"Toes RE","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.11.008"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7799(98)01220-7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020151025412"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(95)93129-W"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9165"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(96)00155-7"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.4049\/jimmunol.147.10.3496","article-title":"Protection of mice from fatal Toxoplasma gondii infection by immunization with p30 antigen in liposomes","volume":"147","author":"Bulow R","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.6.2371-2377.1997"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.4049\/jimmunol.142.12.4441","article-title":"Vaccination against murine cutaneous leishmaniasis by using Leishmania major antigen\/liposomes. 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