{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T08:39:19Z","timestamp":1794645559075,"version":"4.9.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T00:00:00Z","timestamp":1215648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The study was aimed at evaluating the involvement of sTNFR I, sTNFR II, IL\u20101 ra, IL\u201010, IL\u201013 and reactive oxygen species (ROS) in systemic inflammatory response syndrome (SIRS) development in severely burned children and at assessing the prognostic value of the immunological markers studied. The study comprised 37 patients (17 burned children and 20 controls). Serum levels of the markers determined by means of ELISA and respiratory burst of neutrophils as well as p55 and p75 tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) receptor expression using flow cytometry were evaluated twice. The burned children presented significantly higher levels of IL\u201010 and cytokine inhibitors within the first 6\u201324\u2003h after injury compared with controls (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). The decreased oxygen metabolism of neutrophils and increased TNF\u2010\u03b1 receptor expression were found on admission. Moreover, a significant decrease in initially high sTNFR I, sTNFR II, IL\u20101 ra, IL\u201010, IL\u201013 concentrations (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) and reduced expression of TNF\u2010\u03b1 receptors (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) were observed after burn therapy, whereas ROS generation evidently augmented (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Four of our children who developed hypovolaemic shock revealed a significantly lower ROS generation and higher concentrations of soluble TNF\u2010\u03b1 receptors and IL\u20101 ra together with IL\u201010, IL\u201013 compared with children with good outcome (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Our results revealed the involvement of both ROS, soluble TNF\u2010\u03b1 receptors and IL\u20101 ra in the development of SIRS in burned children; their monitoring allows for an assessment of the systemic inflammatory reaction activity. The neutrophil BURSTTEST and IL\u20101 ra might have been clinically helpful markers of SIRS prognosis.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2008.02126.x","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T11:26:52Z","timestamp":1215689212000},"page":"145-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical Evaluation of Proinflammatory Cytokine Inhibitors (sTNFR I, sTNFR II, IL\u20101 ra), Anti\u2010inflammatory Cytokines (IL\u201010, IL\u201013) and Activation of Neutrophils after Burn\u2010induced Inflammation"],"prefix":"10.1111","volume":"68","author":[{"given":"J. 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