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IFN\u2010\u03b3 +874 T\/A and IL\u201010 \u20101082 A\/G polymorphism detection by amplification refractory mutation system technique was carried out for 110 patients with TB, 40 patients with post\u2010BCG lymphadenitis and 118 healthy controls. IFN\u2010\u03b3 +874 A allele was higher in TB and post\u2010BCG patients than those in healthy controls (<jats:italic>P<\/jats:italic>c\u2003=\u20030.006 and 0.002, respectively). IFN\u2010\u03b3 +874 genotype AA was significantly higher in patients with TB than that in control (<jats:italic>P<\/jats:italic>c\u2003=\u20030.015), in extrapulmonary than patients with pulmonary TB (PTB) (<jats:italic>P<\/jats:italic>c\u2003=\u20030.009), and young children with TB below 5\u2003years (<jats:italic>P<\/jats:italic>c\u2003=\u20030.024). No statistically significant differences were observed between patients with TB and controls for the frequency of IL\u201010(\u20101082) alleles or genotypes (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05); however, a statistically significant difference in the frequency of IL\u201010 (\u20101082) GG genotype was found between patients with pulmonary and extrapulmonary TB (<jats:italic>P<\/jats:italic>c\u2003=\u20030.003). Low producer IFN\u2010\u03b3 +874 A\/A genotype is associated with post\u2010BCG lymphadenitis and TB disease especially in younger children below 5\u2003years. IL\u201010\u20101082\u2003G\/G genotype did not exhibit significant association except for increased GG frequency in PTB. Both cytokine polymorphisms have no relation to tuberculin reaction in patients with TB.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2010.02426.x","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T05:37:00Z","timestamp":1275457020000},"page":"358-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Interferon\u2010gamma +874 T\/A and Interleukin\u201010 \u20101082 A\/G Single nucleotide Polymorphism in Egyptian Children with Tuberculosis"],"prefix":"10.1111","volume":"72","author":[{"given":"Y. M.","family":"Mosaad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. E.","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. E.","family":"Tawhid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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