{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:31:46Z","timestamp":1762101106432},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,12,5]],"date-time":"2010-12-05T00:00:00Z","timestamp":1291507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The strategy of using heterogeneous stock (HS) mice has proven to be successful in fine mapping of quantitative trait loci in complex diseases. However, whether these mice can be used for arthritis, encephalomyelitis and autoimmune phenotypes has not been addressed. Here, we screened the Northport HS mice for arthritis phenotypes using three different models: collagen\u2010induced arthritis (CIA), using rat, bovine or chicken collagen type II (CII); recombinant human glucose\u20106\u2010phosphate isomerase (G6PI)\u2010induced arthritis; and collagen antibody\u2013induced arthritis (CAIA). Irrespective of the origin of collagen, we found HS mice to be fairly resistant to CIA and G6PI\u2010induced arthritis, despite the development of antibodies against the respective antigens. On the other hand, HS mice were found to be susceptible for CAIA. Similarly, these mice developed encephalomyelitis (EAE) induced either with mouse or rat spinal cord homogenate (SCH), or with recombinant rat myelin oligodendrocyte glycoprotein, with elevated antibody levels against CNS proteins. Accordingly, we conclude that the use of HS mice for fine mapping and positional cloning of gene(s) involved in CAIA and EAE is possible, but not for collagen\u2010 and G6PI\u2010induced arthritis.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2010.02479.x","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T16:56:23Z","timestamp":1287075383000},"page":"46-52","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Heterogeneous Stock Mice are Susceptible to Encephalomyelitis and Antibody\u2010initiated Arthritis but not to Collagen\u2010 and G6PI\u2010induced Arthritis"],"prefix":"10.1111","volume":"73","author":[{"given":"D.","family":"Klaczkowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Raposo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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