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We recently showed a higher frequency of the interleukin\u20104 (IL\u20104) \u221234TT and \u2212590TT genotype in AgP patients compared to controls (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05). Herein, we demonstrated that this specific IL\u20104 genotype exerts its function by increasing expression of IL\u20104 and STAT6, and producing higher concentrations of IL\u20104 in activated CD4+ cells of patients with AgP. In the present study, we investigated the effects of the IL\u20104\u2010specific genotype on IL\u201013, IL\u20102 and IFN\u2010\u03b3 expression and production in activated CD4+ cells of patients with AgP and healthy controls. Results revealed higher IFN\u2010\u03b3 and IL\u20102 expression and significantly increased IL\u201013 production in the cells of the patients who were homozygous for the \u221234T and \u2212590T alleles in comparison with the patients who were homozygous for the \u221234C and \u2212590C alleles (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05). Results of controls with the \u221234C and \u2212590C alleles were similar to those of AgP with the same genotype. To our knowledge, the present study is the first to show an effect of the \u221234TT and \u2212590TT genotype on IL\u201013 production. There is an increased production of IL\u201013 by the T cells of aggressive periodontitis patients with the IL\u20104 genotype.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2010.02482.x","type":"journal-article","created":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T14:00:28Z","timestamp":1287669628000},"page":"128-134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Production of Interleukin\u201013 is Influenced by the Interleukin\u20104 \u221234TT and \u2212590TT Genotype in Patients with Aggressive Periodontitis"],"prefix":"10.1111","volume":"73","author":[{"given":"J. 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