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Here, we studied the other form of cytotoxic T cell (Tc1) CS in DNFB sensitized BALB\/c mice and determined that similar CS\u2010initiation also is required. We systematically tested each step of the initiation pathway in this model. Thus, DNFB Tc1 CS was significantly impaired in iNKT cell deficient CD1d<jats:sup>\u2212\/\u2212<\/jats:sup> and J\u03b118<jats:sup>\u2212\/\u2212<\/jats:sup> mice, IL4R\u03b1<jats:sup>\u2212\/\u2212<\/jats:sup> and STAT\u20106<jats:sup>\u2212\/\u2212<\/jats:sup> mice, and also in pan B\u2010cell deficient JH<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Further, the Tc1 DNFB CS\u2010initiating component, like Th1 response to TNP\u2010Cl, was elicited by only 1\u2010day after immunization, due to B\u20101 cells. In summary, we show that CS\u2010Initiation also is required in Tc1 CS. Further, we have newly determined regulatory support of both the early and late components of DNFB induced Tc1 CS by iNKT cells and \u03b3\u03b4\u2010T cells. In summary, both iNKT cells and assisting \u03b3\u03b4\u2010T cells are involved in initiating and effector phases of DNFB induced CS.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2011.02522.x","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T18:59:19Z","timestamp":1296154759000},"page":"465-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Participation of Inkt Cells in the Early and Late Components of Tc1\u2010Mediated DNFB Contact Sensitivity: Cooperative Role of \u03b3\u03b4\u2010T Cells"],"prefix":"10.1111","volume":"73","author":[{"given":"P. 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