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The association of the IL\u20104 and IL\u20104R\u03b1 gene polymorphisms with the susceptibility to BD was investigated in this study. DNA samples were obtained from a Turkish population of 97 patients with BD and 76 healthy control subjects. All genotyping (IL\u20104 and IL\u20104R\u03b1) experiments were performed using PCR sequence\u2010specific primers. When compared with the healthy controls, the frequency of IL\u20104 \u22121098 TG and \u2212590 CT genotypes was higher in the patients with BD. Analysis of allele frequencies showed that IL\u20104 \u22121098\u2003G and IL\u20104 \u2212590 T alleles were more common in the patients with BD when compared with healthy controls. Also, IL\u20104 TTC and haplotypes were found to confer BD. Interestingly, we demonstrated that IL\u20104R\u03b1 gene polymorphism seems to be associated with the Pathergy test positivity in patients with BD. Our data suggest that IL\u20104 gene promoter polymorphisms may affect susceptibility to BD and increase risk of developing the disease. However, in order to confirm and assess the association of IL\u20104 and IL\u20104R\u03b1 gene polymorphisms with the BD, large cohort studies are needed.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2011.02532.x","type":"journal-article","created":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T21:22:37Z","timestamp":1297804957000},"page":"594-601","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Interleukin\u20104 Gene Polymorphisms Confer Beh\u00e7et\u2019s Disease in Turkish Population"],"prefix":"10.1111","volume":"73","author":[{"given":"H. 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