{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:26:33Z","timestamp":1783441593326,"version":"3.54.6"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T00:00:00Z","timestamp":1309910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coeliac disease is a chronic inflammation of the intestinal mucosa controlled by gluten\u2010specific T cells restricted by disease\u2010associated HLA\u2010DQ molecules. We have previously reported that mucosal CD11c<jats:sup>+<\/jats:sup> dendritic cells (DCs) are responsible for activation of gluten\u2010reactive T cells within the coeliac lesion. In mice, intestinal CD11c<jats:sup>+<\/jats:sup> DCs comprise several functionally distinct subsets. Here, we report that HLA\u2010DQ<jats:sup>+<\/jats:sup> antigen\u2010presenting cells (APCs) in normal human duodenal mucosa can be divided into four subsets with striking similarities to those described in mice: CD163<jats:sup>+<\/jats:sup>CD11c<jats:sup>\u2212<\/jats:sup> macrophages (74%), and CD11c<jats:sup>+<\/jats:sup> cells expressing either CD163 (7%), CD103 (11%) or CD1c (13%). CD103<jats:sup>+<\/jats:sup> and CD1c<jats:sup>+<\/jats:sup> DCs belonged to partly overlapping populations, whereas CD163<jats:sup>+<\/jats:sup>CD11c<jats:sup>+<\/jats:sup> APCs appeared to be a distinct population. In the coeliac lesion, we found increased density of CD163<jats:sup>+<\/jats:sup>CD11c<jats:sup>+<\/jats:sup> APCs, whereas the density of CD103<jats:sup>+<\/jats:sup> and CD1c<jats:sup>+<\/jats:sup> DCs was decreased, suggesting that distinct subpopulations of APCs in coeliac disease may exert different functions in the pathogenesis.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2011.02549.x","type":"journal-article","created":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T16:29:52Z","timestamp":1299774592000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Density of CD163<sup>+<\/sup>CD11c<sup>+<\/sup> Dendritic Cells Increases and CD103<sup>+<\/sup> Dendritic Cells Decreases in the Coeliac Lesion"],"prefix":"10.1111","volume":"74","author":[{"given":"A.\u2010C. 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