{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:05:28Z","timestamp":1773860728365,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,9,12]],"date-time":"2011-09-12T00:00:00Z","timestamp":1315785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Owing to molecular mimicry, periodontal pathogen carriage may result in a systemic cross\u2010reactive immune response with the host. The analyses were performed to investigate if serum antibody levels to human heat shock protein 60 (HSP60) are associated with the antibody levels and salivary carriage of two periodontal pathogens, <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> and <jats:italic>Porphyromonas gingivalis<\/jats:italic>, as well as with the dental status in patients with acute coronary syndrome (ACS). ACS patients (<jats:italic>n<\/jats:italic>\u2003=\u2003141) were monitored at baseline when entering to hospital, and after 1\u2003week, 3\u2003months and 1\u2003year. Periodontal status was recorded by dental radiographs, and <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> and <jats:italic>P.\u00a0gingivalis<\/jats:italic> were detected by PCR from saliva at baseline. Serum IgG and IgA antibody levels were determined at all time points. All antibody levels remained quite stable during the follow\u2010up. Serum IgG\u2010class antibody levels to <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> and HSP60 had a strong positive correlation with each other at all time points (<jats:italic>r<\/jats:italic>\u223c0.4, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Mean serum IgG antibody levels to HSP60 were significantly higher in the <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> IgG\u2010 and IgA\u2010seropositive than in the seronegative patients, but did not differ between the pathogen carriers compared to the non\u2010carriers. HSP60 antibody levels did not differ significantly between the edentulous, non\u2010periodontitis and periodontitis patients. Despite the observed cross\u2010reactivity in the systemic IgG\u2010class antibody response to HSP60 and <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic>, the pathogen carriage in saliva or the periodontal status did not affect the HSP60 antibody levels in ACS patients.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2011.02584.x","type":"journal-article","created":{"date-parts":[[2011,6,6]],"date-time":"2011-06-06T14:44:46Z","timestamp":1307371486000},"page":"383-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Periodontopathogen\u2010 and Host\u2010Derived Immune Response in Acute Coronary Syndrome"],"prefix":"10.1111","volume":"74","author":[{"given":"H.","family":"Alfakry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Paju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sinisalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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