{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:36:19Z","timestamp":1789583779368,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T00:00:00Z","timestamp":1326153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sporotrichosis is a chronic granulomatous mycosis caused by the dimorphic fungus <jats:italic>Sporothrix schenckii<\/jats:italic>. The immunological mechanisms involved in the prevention and control of sporotrichosis suggest that cell\u2010mediated immunity plays an important role in protecting the host against <jats:italic>S.\u00a0schenckii<\/jats:italic>. Nonetheless, recent data strongly support the existence of protective Abs against this pathogenic fungus. In a previous study, we showed that passive Ab therapy led to a significant reduction in the number of colony forming unit in the organs of mice when the MAb was injected before and during <jats:italic>S.\u00a0schenckii<\/jats:italic> infection. The ability of opsonization to enhance macrophage damage to <jats:italic>S.\u00a0schenckii<\/jats:italic> and subsequent cytokine production was investigated in this work. Here we show that the fungicidal characteristics of macrophages are increased when the fungus is phagocytosed in the presence of inactivated serum from mice infected with <jats:italic>S.\u00a0schenckii<\/jats:italic> or mAb anti\u2010gp70. Additionally, we show an increase in the levels of pro\u2010inflammatory cytokines such as TNF\u2010\u03b1 and IL\u20101\u03b2. This study provides additional support for the importance of antibodies in protecting against <jats:italic>S.\u00a0schenckii<\/jats:italic> and concludes that opsonization is an important process to increase TNF\u2010\u03b1 production and fungus killing by macrophages in experimental sporotrichosis.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2011.02636.x","type":"journal-article","created":{"date-parts":[[2011,9,17]],"date-time":"2011-09-17T03:51:23Z","timestamp":1316231483000},"page":"142-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Antibodies Against <i>Sporothrix schenckii<\/i> Enhance TNF\u2010\u03b1 Production and Killing by Macrophages"],"prefix":"10.1111","volume":"75","author":[{"given":"D.","family":"de Lima Franco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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