{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:53:02Z","timestamp":1761155582042},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:00:00Z","timestamp":1339459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mast cells are abundant in the skin and other peripheral tissues, where they are one of the first immune cells to make contact with invading pathogens. As a result of pathogen recognition, mast cells can be activated and release different preformed and <jats:italic>de novo<\/jats:italic>\u2010synthesized mediators. <jats:italic>Sporothrix schenckii<\/jats:italic> is the fungus that causes sporotrichosis, a worldwide\u2010distributed subcutaneous mycosis considered as an important emerging health problem. It remains unknown whether or not mast cells are activated by <jats:italic>S.\u00a0schenckii.<\/jats:italic> Here, we investigated the <jats:italic>in vitro<\/jats:italic> response of mast cells to conidia of <jats:italic>S.\u00a0schenckii<\/jats:italic> and their <jats:italic>in vivo<\/jats:italic> involvement in sporotrichosis. Mast cells became activated after interaction with conidia, releasing early response cytokines as TNF\u2010\u03b1 and IL\u20106. Although histamine release was not significantly stimulated by <jats:italic>S.\u00a0schenckii,<\/jats:italic> we determined that conidia potentiate histamine secretion induced by compound 48\/80. Furthermore, functional depletion of peritoneal mast cells before <jats:italic>S.\u00a0schenckii<\/jats:italic> infection significantly reduced the severity of cutaneous lesions of the sporotrichosis. These data demonstrate that mast cells are important contributors in the host response to <jats:italic>S.\u00a0schenckii<\/jats:italic> infection, suggesting a role of these cells in the progress of clinical manifestations in sporotrichosis.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2012.02706.x","type":"journal-article","created":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T16:51:36Z","timestamp":1333990296000},"page":"11-20","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Mast Cell Activation by Conidia of <i>Sporothrix schenckii<\/i>: Role in the Severity of Infection"],"prefix":"10.1111","volume":"76","author":[{"given":"Y.","family":"Romo\u2010Lozano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Hern\u00e1ndez\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.10.157"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2004.08.004"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir245"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-280X.1999.00239.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.9.5073-5079.2004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxl097"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2011.02636.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.09.009"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2782"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2005.00372.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.015"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/600070"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0800885"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.06.008"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2008.09.002"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/20.11.938"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2007.07.017"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021806"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.08.012"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00216889"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.4049\/jimmunol.162.3.1685","article-title":"Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL\u201010","volume":"162","author":"Ajuebor MN","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-009-9190-z"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2011.10.007"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-188979"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-1406(08)70024-X"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01373-9"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2003.01175.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02712.x"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.5.2657"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65053-5"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-012-9523-1"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(92)90042-M"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.4.1345"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.6.3577"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01102920"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1086\/377235"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0910531"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.8.5598"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1996.tb04928.x"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2007.00140.x"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3083.2012.02706.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3083.2012.02706.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T11:12:42Z","timestamp":1698664362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3083.2012.02706.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,12]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1365-3083.2012.02706.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3083.2012.02706.x","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,12]]},"assertion":[{"value":"2012-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}