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The hypoxic\u2013ischaemic encephalopathy\u2010induced seizure group consisted of 13 patients, and another 15 normal newborns were enrolled as a control group. All of the initial samples were obtained within the first 24\u2003h of admission, and the second samples were obtained between 48 and 72\u2003h in both groups. Only the third samples were taken in the seizure group on the 5th day. During neonatal seizures, the levels of most cytokines increased within 24\u2003h, and, in particular, the levels of interleukin (IL)\u20108 significantly increased (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). After 48\u201372\u2003h of seizure onset, the levels of most cytokines decreased, especially, IL\u20101Ra; however, IL\u20108 and IL\u201010 remained increased (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). During the prognosis, one patient who was diagnosed with quadriplegic cerebral palsy at 6\u2003months of age presented extreme elevation of IL\u20101beta, IL\u20101Ra, IL\u20106, IL\u20108, IL\u201010 and tumor necrosis factor\u2010alpha in the initial sample, reflecting the severity of brain damage. A significant increase in IL\u20108 may serve as a biomarker for earlier detection of brain damage in neonatal seizure, if detected within 24 and 48\u201372\u2003h of the seizure.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2012.02710.x","type":"journal-article","created":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T14:56:00Z","timestamp":1335452160000},"page":"286-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Serial Examination of Serum IL\u20108, IL\u201010 and IL\u20101Ra Levels is Significant in Neonatal Seizures Induced by Hypoxic\u2013Ischaemic Encephalopathy<sup>1<\/sup>"],"prefix":"10.1111","volume":"76","author":[{"given":"Y. A.","family":"Youn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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