{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:44:59Z","timestamp":1760888699742},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T00:00:00Z","timestamp":1343174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An association exists between chronic infection\u2010induced inflammation, such as periodontitis, and acute coronary syndrome (ACS). We studied the association of serum neutrophil markers, myeloperoxidase (MPO), matrix metalloproteinase (MMP)\u20108, tissue inhibitor of metalloproteinase (TIMP)\u20101 concentrations and MMP\u20108\/TIMP\u20101 ratio, with the risk of recurrent ACS. Radiographic periodontal status was recorded from 141 patients with acute non\u2010Q\u2010wave infarction or unstable angina pectoris, who participated in a double\u2010blind, placebo\u2010controlled study with clarithromycin for 3\u2003months. Serum samples were collected within arrival to the hospital, at 1\u2003week, 3\u2003months and 1\u2003year. Recurrent ACS events were registered during the 1\u2010year follow\u2010up. In the whole population, high serum MPO concentrations at 1\u2003week (fourth quartile versus quartiles 1\u20133) were associated with the risk of recurrent ACS with a relative risk (RR) of 2.52 (95% CI, 1.277\u20134.980; <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.008). In patients without periodontal disease, high MPO concentration at 1\u2003week and 1\u2003year predicted recurrent ACS with RRs of 3.54 (1.600\u20137.831; <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.002) and 2.87 (1.171\u20137.038; <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.021), respectively. In the placebo group, but not in the clarithromycin group, high serum MMP\u20108\/TIMP\u20101 ratio at 1\u2003week predicted recurrent ACS with an RR of 3.23 (1.295\u20138.063; <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.012). Our results suggest that high serum neutrophil markers reflect increased risk of recurrent ACS, especially in patients without periodontal disease and not receiving antimicrobial medication.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2012.02718.x","type":"journal-article","created":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T14:46:36Z","timestamp":1335451596000},"page":"181-187","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The Association of Serum Neutrophil Markers and Acute Coronary 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