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The treatment is highly effective, but could be affected by potential unwanted effects on pro\u2010 and anti\u2010inflammatory biomarkers. In this paper, we review the literature regarding the effect of LDL apheresis on pro\u2010 and anti\u2010inflammatory biomarkers important in atherosclerosis, also as patients in LDL apheresis have high risk for atherosclerotic complications. We discuss the effect of LDL apheresis on complement, cytokines and finally a group of other selected pro\u2010 and anti\u2010inflammatory biomarkers. The complement system is affected by LDL apheresis, and there are differences between different LDL apheresis systems. The plasma separation columns seem to trigger the formation of proinflammatory complement factors including C3a and C5a, while the same anaphylatoxins are adsorbed by the LDL apheresis columns, however, to varying degree. Proinflammatory cytokines are to some extent adsorbed by the LDL apheresis columns, while some of the anti\u2010inflammatory cytokines increase during treatment. Finally, we discuss the effect of apheresis on different biomarkers including C\u2010reactive protein, fibrinogen, adhesion molecules, myeloperoxidase and HDL cholesterol. In conclusion, even if there are differences between pro\u2010 and anti\u2010inflammatory biomarkers during LDL apheresis, the consequences for the patients are largely unknown and larger studies need to be performed. Preferably, they should be comparing the effect of different LDL apheresis columns on the total inflammatory profile, and this should be related to clinical endpoints.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2012.02734.x","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T19:04:18Z","timestamp":1338923058000},"page":"229-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["LDL Apheresis and Inflammation \u2013 Implications for Atherosclerosis"],"prefix":"10.1111","volume":"76","author":[{"given":"A.","family":"Hovland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. T.","family":"Lappeg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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