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However, the introduction of novel legumes to Western countries may have changed this pattern, and in some studies cross\u2010allergy to lupin has been reported in more than 60% of peanut\u2010allergic patients. We wanted to explore cross\u2010reactions among legumes using two newly established mouse models of food allergy. Mice were immunized perorally with fenugreek or lupin with cholera toxin as adjuvant. The mice were challenged with high doses of fenugreek, lupin, peanut or soy, and signs of anaphylactic reactions were observed. Cross\u2010allergic mechanisms were investigated using serum mouse mast cell protease\u20101 (MMCP\u20101), antibody responses, immunoblotting and <jats:italic>ex vivo<\/jats:italic> production of cytokines by spleen cells. Signs of cross\u2010allergy were observed for all the tested legumes in both models. The cross\u2010allergic symptoms were milder and affected fewer mice than the primary allergic responses. The cross\u2010allergy was reflected to a certain extent in the antibody and T\u2010cell responses, but not in serum MMCP\u20101 levels. Cross\u2010allergy to peanut, soy, fenugreek and lupin was observed in lupin\u2010sensitized and fenugreek\u2010sensitized mice. Differences in serological responses between primary allergy and cross\u2010allergy might be due to mediation through different immune mechanisms or reflect different epitope affinity to IgE. These differences need to be further investigated.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2012.02756.x","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T05:04:46Z","timestamp":1342674286000},"page":"387-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cross\u2010allergic Reactions to Legumes in Lupin and Fenugreek\u2010Sensitized Mice"],"prefix":"10.1111","volume":"76","author":[{"given":"N. 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