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Mice were sacrificed at 3, 9, 15\u00a0days post\u2010infection (dpi). Combined treatment of infected mice with gentamicin and ascorbic acid eradicated the bacteria from the blood, spleen and synovial tissue and showed a significant gross reduction in arthritis, reduced serum levels of tumour necrosis factor alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) and interferon gamma (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3). <jats:italic>S.\u00a0aureus<\/jats:italic>\u2010infected mice have demonstrated the disturbed antioxidant status measured in terms of cellular antioxidants like reduced glutathione and antioxidant enzymes such as superoxide dismutase (<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>) and catalase. The same were ameliorated when the animals were co\u2010treated with gentamicin along with ascorbic acid.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2012.02766.x","type":"journal-article","created":{"date-parts":[[2012,8,27]],"date-time":"2012-08-27T21:15:02Z","timestamp":1346102102000},"page":"528-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Gentamicin in Combination with Ascorbic Acid Regulates the severity of <i><scp>S<\/scp>taphylococcus aureus<\/i> Infection\u2013Induced Septic Arthritis in Mice"],"prefix":"10.1111","volume":"76","author":[{"given":"P.","family":"Mal","sequence":"first","affiliation":[{"name":"Department of Physiology, Immunology laboratory University of Calcutta, University Colleges of Science and Technology Calcutta West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of 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