{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:51:39Z","timestamp":1770893499946,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T00:00:00Z","timestamp":1352246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Abstract<\/jats:title>The development of clinically relevant biomarkers is important for diagnosing latent tuberculosis infection (LTBI<\/jats:styled-content>) and active tuberculosis (TB<\/jats:styled-content>) and predicting their prognoses. This study examined whether the responses of multiple cytokines can be used as a biomarker to distinguish the TB<\/jats:styled-content> infection status and mycobacterial load. We analysed the responses of multiple cytokines (IFN<\/jats:styled-content>\u2010\u03b3, IL<\/jats:styled-content>\u20102, IL<\/jats:styled-content>\u201010, IL<\/jats:styled-content>\u201013, IL<\/jats:styled-content>\u201017 and TNF<\/jats:styled-content>\u2010\u03b1) in the supernatant from the QuantiFERON<\/jats:styled-content>\u2010TB G<\/jats:styled-content>old I<\/jats:styled-content>n\u2010T<\/jats:styled-content>ube assay following stimulation of whole blood from the TB<\/jats:styled-content> group (n<\/jats:italic>\u00a0=\u00a032), LTBI<\/jats:styled-content> group (n<\/jats:italic>\u00a0=\u00a019) and healthy controls (n<\/jats:italic>\u00a0=\u00a030) with TB<\/jats:styled-content> antigens (ESAT<\/jats:styled-content>\u20106, CFP<\/jats:styled-content>\u201010 and TB<\/jats:styled-content>7.7). The median responses of IFN<\/jats:styled-content>\u2010\u03b3, IL<\/jats:styled-content>\u20102, IL<\/jats:styled-content>\u201010 and IL<\/jats:styled-content>\u201013 were higher in the LTBI<\/jats:styled-content> and active TB<\/jats:styled-content> groups than in the non\u2010TB<\/jats:styled-content> control group (IFN<\/jats:styled-content>\u2010\u03b3, P<\/jats:italic>\u00a0<\u00a00.001; IL<\/jats:styled-content>\u20102, P<\/jats:italic>\u00a0<\u00a00.001; IL<\/jats:styled-content>\u201010, P<\/jats:italic>\u00a0=\u00a00.012; IL<\/jats:styled-content>\u201013, P<\/jats:italic>\u00a0<\u00a00.001). The median IL<\/jats:styled-content>\u20102\/IFN<\/jats:styled-content>\u2010\u03b3 ratio of the LTBI<\/jats:styled-content> group was higher than that of the active TB<\/jats:styled-content> group (P<\/jats:italic>\u00a0=\u00a00.014) and differed significantly between patients with LTBI<\/jats:styled-content>, patients with smear\u2010negative TB<\/jats:styled-content> and patients with smear\u2010positive TB<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00.027). This difference was especially evident between the patients with LTBI<\/jats:styled-content> and patients with smear\u2010positive TB<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00.047). In conclusion, IFN<\/jats:styled-content>\u2010\u03b3, IL<\/jats:styled-content>\u20102, IL<\/jats:styled-content>\u201010 and IL<\/jats:styled-content>\u201013 can serve as biomarkers for distinguishing TB<\/jats:styled-content> infection. In addition, the IL<\/jats:styled-content>\u20102\/IFN<\/jats:styled-content>\u2010\u03b3 ratio appears to be a biomarker for diagnosing LTBI<\/jats:styled-content> and may be useful as a prognostic factor and for evaluating treatment responses.<\/jats:p>","DOI":"10.1111\/j.1365-3083.2012.02776.x","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T10:00:33Z","timestamp":1346839233000},"page":"580-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The Responses of Multiple Cytokines Following Incubation of Whole Blood from TB<\/scp> Patients, Latently Infected Individuals and Controls with the TB<\/scp> Antigens ESAT<\/scp>\u20106, CFP<\/scp>\u201010 and TB<\/scp>7.7"],"prefix":"10.1111","volume":"76","author":[{"given":"S. Y.","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Pulmonology Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. S.","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Pulmonology Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonology Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonology Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Pulmonology Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010N.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Microbiology Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. 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