{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:41:58Z","timestamp":1791085318286,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,10,30]],"date-time":"2007-10-30T00:00:00Z","timestamp":1193702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Trichothecenes are a closely related family of phytotoxins that are produced by phytopathogenic fungi. In Arabidopsis, expression of <jats:italic>AtNFXL1<\/jats:italic>, a homologue of the putative human transcription repressor <jats:italic>NF\u2010X1<\/jats:italic>, was significantly induced by application of type A trichothecenes, such as T\u20102 toxin. An <jats:italic>atnfxl1<\/jats:italic> mutant growing on medium lacking trichothecenes showed no phenotype, whereas a hypersensitivity phenotype was observed in T\u20102 toxin\u2010treated <jats:italic>atnfxl1<\/jats:italic> mutant plants. Microarray analysis indicated that several defense\u2010related genes (i.e. <jats:italic>WRKY<\/jats:italic>s, <jats:italic>NBS\u2010LRR<\/jats:italic>s, <jats:italic>EDS5<\/jats:italic>, <jats:italic>ICS1<\/jats:italic>, etc.) were upregulated in T\u20102 toxin\u2010treated <jats:italic>atnfxl1<\/jats:italic> mutants compared with wild\u2010type plants. In addition, enhanced salicylic acid (SA) accumulation was observed in T\u20102 toxin\u2010treated <jats:italic>atnfxl1<\/jats:italic> mutants, which suggests that <jats:italic>AtNFXL1<\/jats:italic> functions as a negative regulator of these defense\u2010related genes via an SA\u2010dependent signaling pathway. We also found that expression of <jats:italic>AtNFXL1<\/jats:italic> was induced by SA and flg22 treatment. Moreover, the <jats:italic>atnfxl1<\/jats:italic> mutant was less susceptible to a compatible phytopathogen, <jats:italic>Pseudomonas syringae<\/jats:italic> pv. tomato strain DC3000 (<jats:italic>Pst<\/jats:italic> DC3000). Taken together, these results indicate that <jats:italic>AtNFXL1<\/jats:italic> plays an important role in the trichothecene response, as well as the general defense response in Arabidopsis.<\/jats:p>","DOI":"10.1111\/j.1365-313x.2007.03353.x","type":"journal-article","created":{"date-parts":[[2008,1,25]],"date-time":"2008-01-25T10:49:49Z","timestamp":1201258189000},"page":"450-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["<i>AtNFXL1<\/i>, an Arabidopsis homologue of the human transcription factor NF\u2010X1, functions as a negative regulator of the trichothecene phytotoxin\u2010induced defense 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