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Although the biology of each group is unique, common patterns have become apparent. Opium poppy (<jats:italic>Papaver somniferum<\/jats:italic>), which produces several benzylisoquinoline alkaloids, and Madagascar periwinkle (<jats:italic>Catharanthus roseus<\/jats:italic>), which accumulates an array of monoterpenoid indole alkaloids, have emerged as the premier organisms used to study plant alkaloid metabolism. The status of these species as model systems results from decades of research on the chemistry, enzymology and molecular biology responsible for the biosynthesis of valuable pharmaceutical alkaloids. Opium poppy remains the only commercial source for morphine, codeine and semi\u2010synthetic analgesics, such as oxycodone, derived from thebaine. <jats:italic>Catharanthus roseus<\/jats:italic> is the only source for the anti\u2010cancer drugs vinblastine and vincristine. Impressive collections of cDNAs encoding biosynthetic enzymes and regulatory proteins involved in the formation of benzylisoquinoline and monoterpenoid indole alkaloids are now available, and the rate of gene discovery has accelerated with the application of genomics. Such tools have allowed the establishment of models that describe the complex cell biology of alkaloid metabolism in these important medicinal plants. A suite of biotechnological resources, including genetic transformation protocols, has allowed the application of metabolic engineering to modify the alkaloid content of these and related species. An overview of recent progress on benzylisoquinoline and monoterpenoid indole alkaloid biosynthesis in opium poppy and <jats:italic>C. roseus<\/jats:italic> is presented.<\/jats:p>","DOI":"10.1111\/j.1365-313x.2008.03438.x","type":"journal-article","created":{"date-parts":[[2008,5,9]],"date-time":"2008-05-09T13:10:13Z","timestamp":1210338613000},"page":"763-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":232,"title":["Opium poppy and Madagascar periwinkle: model non\u2010model systems to investigate alkaloid biosynthesis in plants"],"prefix":"10.1111","volume":"54","author":[{"given":"Peter J.","family":"Facchini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,5,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.105.059287"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1033"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7652.2007.00293.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00391333"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1385\/ABAB:97:2:135"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.106.045682"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)98230-X"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3054.1997.tb05407.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2007.07.008"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004250100582"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.015396"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2004.02030.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(02)00483-1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004250050338"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11103-006-9025-y"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0981-9428(00)00781-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2006.10.009"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1071\/FP03126"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106405200"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.104.041012"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)03045-9"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2006.02670.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01022-9"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11103-005-3095-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.85.4.1099"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.8.2582"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(20001001)21:16<3500::AID-ELPS3500>3.0.CO;2-O"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(92)80020-F"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)95153-7"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.22.9969"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00425-004-1380-9"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-006-9047-8"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1099-4831(06)63001-0"},{"key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"26684","DOI":"10.1016\/S0021-9258(18)47073-1","article-title":"Differential and tissue\u2010specific expression of a gene family for tyrosine\/dopa decarboxylase in opium poppy","volume":"269","author":"Facchini P.J.","year":"1994","journal-title":"J. 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