{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T17:18:25Z","timestamp":1794503905896,"version":"4.9.1"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T00:00:00Z","timestamp":1309910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    calmodulin binding protein 60g (CBP60g) contributes to production of salicylic acid (SA) in response to recognition of microbe\u2010associated molecular patterns (MAMPs) such as flg22, a fragment of bacterial flagellin. Calmodulin binding is required for the function of CBP60g in limiting growth of the bacterial pathogen\n                    <jats:italic>Pseudomonas syringae<\/jats:italic>\n                    pv.\u00a0\n                    <jats:italic>maculicola<\/jats:italic>\n                    (\n                    <jats:italic>Pma<\/jats:italic>\n                    ) ES4326 and activation of SA synthesis. Here, we describe a closely related protein, SARD1. Unlike CBP60g, SARD1 does not bind calmodulin. Growth of\n                    <jats:italic>Pma<\/jats:italic>\n                    ES4326 is enhanced in\n                    <jats:italic>sard1<\/jats:italic>\n                    mutants. In\n                    <jats:italic>cbp60g sard1<\/jats:italic>\n                    double mutants, growth of\n                    <jats:italic>Pma<\/jats:italic>\n                    ES4326 is greatly enhanced, and SA levels and expression of\n                    <jats:italic>PR\u20101<\/jats:italic>\n                    and\n                    <jats:italic>SID2<\/jats:italic>\n                    are dramatically reduced. Expression profiling placed the CBP60g\/SARD1 node between the PAD4\/EDS1 and SA nodes in the defense signaling network, and indicated that CBP60g and SARD1 affect defense responses in addition to SA production. A DNA motif bound by CBP60g and SARD1, GAAATTT, was significantly over\u2010represented in promoters of CBP60g\/SARD1\u2010dependent genes, suggesting that expression of these genes is modulated by CBP60g\/SARD1 binding. Gene expression patterns showed a stronger effect of\n                    <jats:italic>cbp60g<\/jats:italic>\n                    mutations soon after activation of a defense response, and a stronger effect of\n                    <jats:italic>sard1<\/jats:italic>\n                    mutations at later times. The results are consistent with a model in which CBP60g and SARD1 comprise a partially redundant protein pair that is required for activation of SA production as well as other defense responses, with CBP60g playing a more important role early during the defense response, and SARD1 to playing a more important role later.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-313x.2011.04655.x","type":"journal-article","created":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T12:52:56Z","timestamp":1306327976000},"page":"1029-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":299,"title":["CBP60g and SARD1 play partially redundant critical roles in salicylic acid signaling"],"prefix":"10.1111","volume":"67","author":[{"given":"Lin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Tsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Truman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanao","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le 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