{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T15:21:25Z","timestamp":1793892085555,"version":"4.8.0"},"reference-count":71,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T00:00:00Z","timestamp":1310601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The molecular interactions between Arabidopsis and the pathogenic powdery mildew <jats:italic>Golovinomyces cichoracearum<\/jats:italic> were studied by characterizing a disease\u2010resistant Arabidopsis mutant <jats:italic>atg2\u20102.<\/jats:italic> The <jats:italic>atg2\u20102<\/jats:italic> mutant showed enhanced resistance to powdery mildew and dramatic mildew\u2010induced cell death as well as early senescence phenotypes in the absence of pathogens. Defense\u2010related genes were constitutively activated in <jats:italic>atg2\u20102<\/jats:italic>. In <jats:italic>atg2\u20102<\/jats:italic> mutants, spontaneous cell death, early senescence and disease resistance required the salicylic acid (SA) pathway, but interestingly, mildew\u2010induced cell death was not fully suppressed by inactivation of SA signaling. Thus, cell death could be uncoupled from disease resistance, suggesting that cell death is not sufficient for resistance to powdery mildew. <jats:italic>ATG2<\/jats:italic> encodes autophagy\u2010related 2, a protein known to be involved in the early steps of autophagosome biogenesis. The <jats:italic>atg2\u20102<\/jats:italic> mutant exhibited typical autophagy defects in autophagosome formation. Furthermore, mutations in several other <jats:italic>ATG<\/jats:italic> genes, including <jats:italic>ATG5<\/jats:italic>, <jats:italic>ATG7<\/jats:italic> and <jats:italic>ATG10<\/jats:italic>, exhibited similar powdery mildew resistance and mildew\u2010induced cell death phenotypes. Taken together, our findings provide insights into the role of autophagy in cell death and disease resistance, and may indicate general links between autophagy, senescence, programmed cell death and defense responses in plants.<\/jats:p>","DOI":"10.1111\/j.1365-313x.2011.04669.x","type":"journal-article","created":{"date-parts":[[2011,6,6]],"date-time":"2011-06-06T14:40:03Z","timestamp":1307371203000},"page":"74-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":166,"title":["ATG2, an autophagy\u2010related protein, negatively affects powdery mildew resistance and mildew\u2010induced cell death in Arabidopsis"],"prefix":"10.1111","volume":"68","author":[{"given":"Yiping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc T.","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingzhong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI.1999.12.12.1031"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5423.2148"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086391"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.105.039982"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.6.12.1845"},{"key":"e_1_2_6_7_1","first-page":"1573","article-title":"The cpr5 mutant of Arabidopsis expresses both NPR1\u2010dependent and NPR1\u2010independent resistance","volume":"9","author":"Bowling S.A.","year":"1997","journal-title":"Plant Cell"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.218202"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81858-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5345.1963"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI.2000.13.12.1312"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05999"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2010.04166.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313x.1998.00343.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.150005697"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02076"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2005.02787.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.147660"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2005.02396.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.14.6602"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81911-X"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204630200"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.phyto.42.040803.140421"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.2003.01794.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2307\/3869877"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.10.6.947"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.1.373"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.phyto.43.040204.135923"},{"key":"e_1_2_6_30_1","first-page":"513","article-title":"Exploiting the triple response of Arabidopsis to identify ethylene\u2010related mutants","volume":"2","author":"Guzman P.","year":"1990","journal-title":"Plant Cell"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.011024"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.036"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcp\/pcl031"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.23.13583"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05286"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI.2004.17.5.511"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.151258398"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.05.046"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01620"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2245"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.15.1.1"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2011.04553.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI.2001.14.10.1131"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1119409"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.03.007"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.771"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313x.2000.00836.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.010376"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086716"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803180200"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.8.11.2033"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5056"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.107.086199"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.2307\/3761274"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2007.7"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00402-7"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2007.01050.x"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2005.02523.x"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.105.060400"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2006.02769.x"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.105.060673"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.030531997"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2229-7-35"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.108.130013"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102342200"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005934428906"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/35107108"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.006940"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5366.1091"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2005.02397.x"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.104.025395"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.109.068635"}],"container-title":["The Plant Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-313X.2011.04669.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-313X.2011.04669.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T08:43:06Z","timestamp":1698741786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-313X.2011.04669.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,14]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1111\/j.1365-313X.2011.04669.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-313x.2011.04669.x","archive":["Portico"],"relation":{},"ISSN":["0960-7412","1365-313X"],"issn-type":[{"value":"0960-7412","type":"print"},{"value":"1365-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,14]]},"assertion":[{"value":"2011-07-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}