{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:39:38Z","timestamp":1792805978195,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T00:00:00Z","timestamp":1311638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Cyanogenic glucosides are amino acid\u2010derived defence compounds found in a large number of vascular plants. Their hydrolysis by specific \u03b2\u2010glucosidases following tissue damage results in the release of hydrogen cyanide. The\n                    <jats:italic>cyanogenesis deficient1<\/jats:italic>\n                    (\n                    <jats:italic>cyd1<\/jats:italic>\n                    ) mutant of\n                    <jats:italic>Lotus japonicus<\/jats:italic>\n                    carries a partial deletion of the\n                    <jats:italic>CYP79D3<\/jats:italic>\n                    gene, which encodes a cytochrome P450 enzyme that is responsible for the first step in cyanogenic glucoside biosynthesis. The genomic region surrounding\n                    <jats:italic>CYP79D3<\/jats:italic>\n                    contains genes encoding the CYP736A2 protein and the UDP\u2010glycosyltransferase UGT85K3. In combination with\n                    <jats:italic>CYP79D3<\/jats:italic>\n                    , these genes encode the enzymes that constitute the entire pathway for cyanogenic glucoside biosynthesis. The biosynthetic genes for cyanogenic glucoside biosynthesis are also co\u2010localized in cassava (\n                    <jats:italic>Manihot esculenta<\/jats:italic>\n                    ) and sorghum (\n                    <jats:italic>Sorghum bicolor<\/jats:italic>\n                    ), but the three gene clusters show no other similarities. Although the individual enzymes encoded by the biosynthetic genes in these three plant species are related, they are not necessarily orthologous. The independent evolution of cyanogenic glucoside biosynthesis in several higher plant lineages by the repeated recruitment of members from similar gene families, such as the CYP79s, is a likely scenario.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-313x.2011.04685.x","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T06:53:40Z","timestamp":1309416820000},"page":"273-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":180,"title":["Genomic clustering of cyanogenic glucoside biosynthetic genes aids their identification in\n                    <i>Lotus japonicus<\/i>\n                    and suggests the repeated evolution of this chemical defence pathway"],"prefix":"10.1111","volume":"68","author":[{"given":"Adam 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