{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:16:03Z","timestamp":1781712963493,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,5]],"date-time":"2012-01-05T00:00:00Z","timestamp":1325721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Journal"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Regulation of the root growth pattern is an important control mechanism during plant growth and propagation. To better understand alterations in root growth direction in response to environmental stimuli, we have characterized an\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    mutant,\n                    <jats:italic>wavy growth\u20033<\/jats:italic>\n                    (\n                    <jats:italic>wav3<\/jats:italic>\n                    ), whose roots show a short\u2010pitch pattern of wavy growth on inclined agar medium. The\n                    <jats:italic>wav3<\/jats:italic>\n                    mutant shows a greater curvature of root bending in response to gravity, but a smaller curvature in response to light, suggesting that it is a root gravitropism\u2010enhancing mutation. This\n                    <jats:italic>wav3<\/jats:italic>\n                    phenotype also suggests that enhancement of the gravitropic response in roots strengthens root tip impedance after contact with the agar surface and\/or causes an increase in subsequent root bending in response to obstacle\u2010touching stimulus in these mutants.\n                    <jats:italic>WAV3<\/jats:italic>\n                    encodes a protein with a RING finger domain, and is mainly expressed in root tips. RING\u2010containing proteins often function as an E3 ubiquitin ligase, and the WAV3 protein shows such activity\n                    <jats:italic>in vitro<\/jats:italic>\n                    . There are three genes homologous to\n                    <jats:italic>WAV3<\/jats:italic>\n                    in the Arabidopsis genome [\n                    <jats:italic>EMBRYO SAC DEVELOPMENT ARREST\u200340<\/jats:italic>\n                    (\n                    <jats:italic>EDA40<\/jats:italic>\n                    ),\n                    <jats:italic>WAVH1<\/jats:italic>\n                    and\n                    <jats:italic>WAVH2<\/jats:italic>\n                    \u200a], and\n                    <jats:italic>wav3 wavh1 wavh2<\/jats:italic>\n                    triple mutants show marked root gravitropism abnormalities. This genetic study indicates that\n                    <jats:italic>WAV3<\/jats:italic>\n                    functions positively rather than negatively in root gravitropism, and that enhancement of the gravitropic response in\n                    <jats:italic>wav3<\/jats:italic>\n                    roots is dependent upon the function of\n                    <jats:italic>WAVH2<\/jats:italic>\n                    in the absence of WAV3. Hence, our results demonstrate that the WAV3 family of proteins are E3 ligases that are required for root gravitropism in Arabidopsis.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-313x.2011.04870.x","type":"journal-article","created":{"date-parts":[[2011,11,28]],"date-time":"2011-11-28T17:41:22Z","timestamp":1322502082000},"page":"303-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The WAVY GROWTH\u20033 E3 ligase family controls the gravitropic response in Arabidopsis roots"],"prefix":"10.1111","volume":"70","author":[{"given":"Tatsuya","family":"Sakai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Haga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumie","family":"Ishiguro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1369"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086391"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5277.948"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.102.019182"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.15112"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313x.1998.00343.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.011841"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.052028ce"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02085"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00014672"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2002.1088"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000881200"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5346.2120"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.019901"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.003533"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00392808"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609929104"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.14.2175"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4161\/psb.4.3.7959"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.104.028530"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.23.6903"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.250.4978.274"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1071\/PP9920439"},{"key":"e_1_2_6_25_1","first-page":"665","volume-title":"Arabidopsis","author":"Okada 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