{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:31:49Z","timestamp":1782448309241,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T00:00:00Z","timestamp":1158883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold><jats:sc>summary<\/jats:sc><\/jats:bold> In order to determine gene frequencies of human platelet antigen (HPA) and establish a panel of accredited HPA\u20101a, \u20102a, \u20104a, \u20105a and \u20106a\u2010negative donors as well as an HPA\u2010typed platelet donor registry, a total of 1000 Chinese donors of Han nationality (500 from north China and 500 from south China) were typed for HPA\u20101 through \u201016 using a DNA\u2010based polymerase chain reaction with sequence\u2010specific primers genotyping method. The gene frequencies of<jats:italic> HPA\u20101b<\/jats:italic>,<jats:italic> \u20102b<\/jats:italic>,<jats:italic> \u20103b<\/jats:italic>,<jats:italic> \u20104b<\/jats:italic>,<jats:italic> \u20105b<\/jats:italic>,<jats:italic> \u20106bw<\/jats:italic>,<jats:italic> \u201010bw <\/jats:italic>and<jats:italic> \u201015b <\/jats:italic>were 0\u00b70060, 0\u00b70485, 0\u00b74055, 0\u00b70045, 0\u00b70140, 0\u00b70135, 0\u00b70005 and 0\u00b74680, respectively. The<jats:italic> HPA\u20107bw<\/jats:italic>,<jats:italic> \u20108bw<\/jats:italic>,<jats:italic> \u20109bw<\/jats:italic>,<jats:italic> \u201011bw<\/jats:italic>,<jats:italic> \u201012bw<\/jats:italic>,<jats:italic> \u201013bw<\/jats:italic>,<jats:italic> \u201014bw <\/jats:italic>and<jats:italic> \u201016bw <\/jats:italic>alleles were not found. The<jats:italic> HPA\u20102b <\/jats:italic>and<jats:italic> \u20105b <\/jats:italic>homozygous donors were detected at low frequencies. The HPA mismatch probabilities potentially leading to alloimmunization in random platelet transfusion vary with a region from 0\u00b71% to 37% depending on the distribution patterns of common and less common alleles in each system. This study provides a useful HPA\u2010typed plateletpheresis donor registry in China and could improve platelet antibody detection and HPA\u2010matched platelet transfusion in alloimmune thrombocytopenic patients.<\/jats:p>","DOI":"10.1111\/j.1365-3148.2006.00687.x","type":"journal-article","created":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T12:59:12Z","timestamp":1158929952000},"page":"369-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Establishment of an HPA\u20101\u2010 to \u201016\u2010typed platelet donor registry in China"],"prefix":"10.1111","volume":"16","author":[{"given":"M. L.","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Z.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. H.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C.","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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