{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:23:52Z","timestamp":1789025032731,"version":"build-2803163510"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,27]],"date-time":"2007-12-27T00:00:00Z","timestamp":1198713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p><jats:bold><jats:sc>summary<\/jats:sc><\/jats:bold> The Colton (Co<jats:sup>a<\/jats:sup>) antigen is of high frequency; its incidence in Caucasians is about 99.8%. Reports on haemolytic transfusion reactions and haemolytic disease of the foetus\/newborn (HDFN) due to anti\u2010Co<jats:sup>a<\/jats:sup> are rare. We report a severe HDFN due to anti\u2010Co<jats:sup>a<\/jats:sup>. The first child of the mother was healthy. The second died a few hours after delivery because of hydrops fetalis, likely due to HDFN; anti\u2010Co<jats:sup>a<\/jats:sup> in the maternal serum, the father typed as Co(a+). The third pregnancy was followed up by the measurements of anti\u2010Co<jats:sup>a<\/jats:sup> titre (additional antibodies were excluded), its functional activity by the chemiluminescence test (CLT) and the Doppler flow in the middle cerebral artery of the foetus. Increased values of antibody titre up to 128, the CLT to 30% and multiplex of median of the peak systolic velocity to 1\u00b771 indicated haemolytic disease and the necessity for an intrauterine transfusion. The foetus received the maternal red blood cells (RBCs). Delivery had to be by Caesarean section for obstetrical reasons at 34\u2010week gestation. The newborn (anti\u2010Co<jats:sup>a<\/jats:sup> on red cells and in plasma, the rise of the bilirubin concentration up to 333 \u03bcmol L<jats:sup>\u22121<\/jats:sup>) had four exchange transfusions: the first of maternal RBCs, the remaining of donor\u2019s Co(a+) cells and one top\u2010up transfusion. The baby was discharged in good health. Anti\u2010Co<jats:sup>a<\/jats:sup> was responsible for severe HDFN. Proper monitoring during pregnancy and antenatal and post\u2010natal therapy were successful. This is the second severe published HDFN due to anti\u2010Co<jats:sup>a<\/jats:sup>.<\/jats:p>","DOI":"10.1111\/j.1365-3148.2007.00799.x","type":"journal-article","created":{"date-parts":[[2008,2,11]],"date-time":"2008-02-11T09:05:42Z","timestamp":1202720742000},"page":"71-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anti\u2010Co<sup>a<\/sup> implicated in severe haemolytic disease of the foetus and newborn"],"prefix":"10.1111","volume":"18","author":[{"given":"B.","family":"Michalewska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wielgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Zupanska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bartkowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.21307\/immunohematology-2019-543","article-title":"Acute hemolytic transfusion reaction caused by anti\u2010Coa","volume":"17","author":"Covin R.B.","year":"2001","journal-title":"Immunohematology"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470987018"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10059.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1967.tb03353.x"},{"key":"e_1_2_5_6_1","article-title":"Anti\u2010Coa implicated in delay hemolytic transfusion reaction","volume":"22","author":"Kitzke H.M.","year":"1982","journal-title":"Transfusion"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1976.16176130840.x"},{"key":"e_1_2_5_8_1","first-page":"1302","article-title":"Anti\u2010Coa and severe haemolytic disease of the newborn","volume":"47","author":"Simpson W.K.H","year":"1973","journal-title":"South African Medical Journal"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1970.tb01429.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2001.00033.x"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3148.2007.00799.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3148.2007.00799.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T04:01:52Z","timestamp":1696910512000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3148.2007.00799.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1365-3148.2007.00799.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3148.2007.00799.x","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"2008-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}