{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:50:19Z","timestamp":1761155419287},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,12,6]],"date-time":"2007-12-06T00:00:00Z","timestamp":1196899200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p><jats:bold><jats:sc>summary<\/jats:sc><\/jats:bold> To study the relationship between antibodies detected in patients\u2019 and\/or donors\u2019 sera and the clinical features of acute non\u2010haemolytic transfusion reactions (ANHTRs), and to determine any gender\u2010related difference. ANHTRs range from urticaria to transfusion\u2010related acute lung injury (TRALI). Antibodies to human leukocyte antigen (HLA), granulocytes, platelets, and\/or plasma proteins are implicated in some of the ANHTRs. A higher antibody positivity is expected for females than for males. A comparative study of ANHTRs for antibody positivity and their clinical features between females and males for both patients and donors is helpful for characterizing ANHTRs including TRALI more clearly, but such studies are few and outdated. Two hundred and twenty\u2010three ANHTR cases reported by 45 hospitals between October 2000 and July 2005 were analysed. The patients and 196 donors of suspect blood products were screened for antibodies to HLA Class I, HLA Class II, granulocytes, and platelets. The patients were also screened for anti\u2010plasma protein antibodies. The types and severity of ANHTR did not differ significantly between female and male patients. The frequency of the anti\u2010HLA antibodies, but not that of the non\u2010HLA antibodies, was significantly higher in females. Non\u2010HLA antibodies were significantly associated with severe reactions in females. All the TRALI cases had predisposing risk factors for acute lung injury, and 60% of the cases showed anti\u2010leucocyte antibodies. Although the anti\u2010HLA antibodies were detected more frequently in females than males, no significant association of ANHTRs including TRALI with gender, not only for patients, but also for donors, could be shown in this study.<\/jats:p>","DOI":"10.1111\/j.1365-3148.2007.00802.x","type":"journal-article","created":{"date-parts":[[2010,9,20]],"date-time":"2010-09-20T10:33:21Z","timestamp":1284978801000},"page":"455-465","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of acute non\u2010haemolytic transfusion reactions in female and male patients receiving female or male blood components"],"prefix":"10.1111","volume":"17","author":[{"given":"S.","family":"Imoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Saigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Nose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Bouike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1999.7710044.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.04183.x"},{"key":"e_1_2_6_4_1","first-page":"95","article-title":"Nonhemolytic, noninfectious transfusion reactions","volume":"18","author":"Barton J.C","year":"1981","journal-title":"Seminers in Hematology"},{"key":"e_1_2_6_5_1","unstructured":"Blood Products Research Organization. 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