{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:57:01Z","timestamp":1761541021891},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T00:00:00Z","timestamp":1289347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p> <jats:bold>Background:<\/jats:bold> It is known that 20\u201330% of fresh frozen plasma (FFP) is used in intensive care units (ICUs), but little is known about variations in decision making between clinicians in relation to coagulopathy management. Our aim was to describe ICU clinicians' beliefs and practice in relation to FFP treatment of non\u2010bleeding coagulopathic critically ill patients.<\/jats:p><jats:p> <jats:bold>Methods:<\/jats:bold> Two patient\u2010based scenarios were developed and sent to 2700 members of two UK intensive care professional societies. Scenario 1 was a non\u2010bleeding septic patient with coagulopathy; scenario 2 was a non\u2010bleeding critically ill patient with hepatic cirrhosis and coagulopathy. Responses were sought in relation to FFP prophylaxis, and prior to central venous cannulation. A supplementary question asked clinicians' view of prophylaxis in relation to other ICU procedures.<\/jats:p><jats:p> <jats:bold>Results:<\/jats:bold> Two\u2010thousand\u2010and\u2010seven\u2010hundred clinicians were surveyed from whom 601 responses were received (22\u00b73% response rate). For scenario 1 52% of respondents stated that they would never routinely administer prophylactic FFP, but this decreased to 9% when central venous cannulation was planned (<jats:italic>P<\/jats:italic> &lt; 0\u00b701). There was wide variation in the \u2018trigger\u2019 INR (international normalised ratio) value used prior to central vein cannulation, the most common range being 2\u00b70\u20132\u00b74. For scenario 2, responses were very similar. More than 80% of clinicians stated that they would routinely treat coagulopathy prior to lumbar puncture, epidural catheterisation, intracranial pressure monitoring and tracheostomy; and 54% prior to chest drain insertion.<\/jats:p><jats:p> <jats:bold>Conclusion:<\/jats:bold> Our survey demonstrated a wide range of responses consistent with important variations in clinical practice and substantial clinical uncertainty in relation to FFP treatment for non\u2010bleeding ICU patients.<\/jats:p>","DOI":"10.1111\/j.1365-3148.2010.01049.x","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T08:47:08Z","timestamp":1289378828000},"page":"124-129","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A national clinical scenario\u2010based survey of clinicians' attitudes towards fresh frozen plasma transfusion for critically ill patients"],"prefix":"10.1111","volume":"21","author":[{"given":"D. M.","family":"Watson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Stanworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wyncoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. F.","family":"McAuley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. D.","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"Biggin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. S.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00891.x"},{"key":"e_1_2_6_3_1","volume-title":"Designing and Conducting Health Surveys.","author":"Aday L.A.","year":"1996"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318186b6f3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04868.x"},{"key":"e_1_2_6_6_1","first-page":"1347","article-title":"Reported response rates to mailed physician questionnaires.","volume":"35","author":"Cummings S.A.","year":"2001","journal-title":"Health Services Research"},{"key":"e_1_2_6_7_1","first-page":"324","article-title":"Predicting hemorrhage using preoperative coagulation screening assays.","volume":"3","author":"Dzik W.H.","year":"2004","journal-title":"Current Hematology Reports"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/NQXHUG7HND78LFFK"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-3048"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000269370.59214.97"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0841"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181844677"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00998.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-10-200411160-00008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00546.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2006.05.002"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2007.1.179"},{"key":"e_1_2_6_18_1","article-title":"The use of fresh frozen plasma in England: high levels of inappropriate use in adults and children.","author":"Stanworth S.J.","year":"2010","journal-title":"Transfusion"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.00427.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181eb9d2b"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3148.2010.01049.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3148.2010.01049.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T16:07:17Z","timestamp":1697299637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3148.2010.01049.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,10]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1111\/j.1365-3148.2010.01049.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3148.2010.01049.x","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,10]]},"assertion":[{"value":"2010-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}