{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:33:27Z","timestamp":1761975207023},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,5,23]],"date-time":"2011-05-23T00:00:00Z","timestamp":1306108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p> <jats:bold>Background:<\/jats:bold> Intravenous immunoglobulin (IVIG) is used to treat an increasing number of conditions. IVIG contains immunoglobulin G (IgG) directed against many targets, including red blood cell (RBC) antigens.<\/jats:p><jats:p> <jats:bold>Methods\/materials:<\/jats:bold> We report on three patients identified within a 7\u2010month period in a single institution who developed haemolysis because of passively transferred anti\u2010A.<\/jats:p><jats:p> <jats:bold>Results:<\/jats:bold> The patients were a 34\u2010year\u2010old A (non\u2010A<jats:sub>1<\/jats:sub>) D\u2010positive male with aplastic anaemia, a 61\u2010year\u2010old A<jats:sub>1<\/jats:sub> D\u2010negative female with myasthenia gravis and a 57\u2010year\u2010old AB D\u2010positive female lung transplant recipient. The haemoglobin decreased from 11\u00b71 to 5\u00b73 g dL<jats:sup>\u22121<\/jats:sup> over 2 days, 12\u00b78 to 7\u00b78 g dL<jats:sup>\u22121<\/jats:sup> over 6 days and 7\u00b78 to 6\u00b70 g dL<jats:sup>\u22121<\/jats:sup> over several hours, respectively. All three patients had a negative antibody screen, positive direct antiglobulin test for IgG only and an elution containing anti\u2010A<jats:sub>1<\/jats:sub> reactivity. The patients were transfused with O RBC with an appropriate rise in haemoglobin.<\/jats:p><jats:p> <jats:bold>Conclusion:<\/jats:bold> These cases illustrate the potential severity of haemolysis after IVIG because of passively transferred antibodies to blood group antigens. Lack of recognition of IVIG as a cause for haemolysis by clinicians may be further confounded if routine testing fails to detect the passively transferred ABO blood group antibodies.<\/jats:p>","DOI":"10.1111\/j.1365-3148.2011.01078.x","type":"journal-article","created":{"date-parts":[[2011,5,23]],"date-time":"2011-05-23T10:33:56Z","timestamp":1306146836000},"page":"267-270","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Haemolysis after treatment with intravenous immunoglobulin due to anti\u2010A"],"prefix":"10.1111","volume":"21","author":[{"given":"S.","family":"Morgan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sorensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Vercellotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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