{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:59:38Z","timestamp":1792792778283,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,6,9]],"date-time":"2011-06-09T00:00:00Z","timestamp":1307577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p><jats:bold>Objectives\/Aims:<\/jats:bold> We investigated the incidence of immunoglobulin A (IgA) deficiency in Chinese population.<\/jats:p><jats:p><jats:bold>Background:<\/jats:bold> The frequency of IgA deficiency, defined as a serum IgA level of &lt;0\u00b705 mg dL<jats:sup>\u22121<\/jats:sup>, has been broadly studied in different ethnic groups. Individuals with IgA deficiency may form specific antibodies against IgA, which can cause an anaphylactic response when the patient receives an IgA\u2010containing blood transfusion.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A sandwich enzyme\u2010linked immunosorbent assay was performed to screen for IgA deficiency and particle gel immunoassay used for confirmation. IgA antibodies were further detected by the DiaMed anti\u2010IgA test in IgA\u2010deficient blood donors.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Of the total 22 609 healthy blood donors screened, only seven cases were confirmed as having IgA deficiency (&lt;0\u00b705 mg dL<jats:sup>\u22121<\/jats:sup>). Another seven cases displayed relative IgA deficiencies, with mean IgA concentrations ranging from 0\u00b739 to 3\u00b770 mg dL<jats:sup>\u22121<\/jats:sup>. Anti\u2010IgA was identified in 2 of the 14 IgA\u2010deficient blood donors whose IgA levels were &lt;5 mg dL<jats:sup>\u22121<\/jats:sup>. Estimation of the theoretical risk for IgA anaphylactic transfusion reaction was 0\u00b7009%.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The prevalence of IgA deficiency in Chinese is low. However, potential risks exist in performing blood transfusion to IgA\u2010deficient persons, and measures should be taken to reduce IgA anaphylaxis.<\/jats:p>","DOI":"10.1111\/j.1365-3148.2011.01082.x","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T08:51:12Z","timestamp":1307695872000},"page":"338-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Prevalence of immunoglobulin A deficiency in Chinese blood donors and evaluation of anaphylactic transfusion reaction risk"],"prefix":"10.1111","volume":"21","author":[{"given":"M. L.","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. 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