{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:56:08Z","timestamp":1787014568709,"version":"build-2736575974"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T00:00:00Z","timestamp":1315180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Patients with beta\u2010thalassaemia major require life\u2010long blood transfusion with the aim of achieving normal growth and development whilst minimising iron overload. A pre\u2010transfusion Hb between 9\u00b75 and 10 g\/dL is thought to achieve this balance. UK consensus is that fresh blood (less than 14 days) is better at maintaining this target pre\u2010transfusion Hb but there is no firm stipulation in place and no robust evidence supporting this.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    After introduction of a universal fresh blood policy for adult beta\u2010thalassaemics in 2010, we reviewed locally transfused adult patients to determine if there was any significant difference in pre\u2010transfusion Hb using fresh blood. Nine adult thalassaemic patients were analysed for two consecutive 6\u2010month periods in 2009 and 2010 (periods 1 and 2).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Mean pre\u2010transfusion Hb was significantly higher by an average of 0\u00b75 g\/dL in period 2 than period 1 (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0\u00b705). The average unit age was 18 vs 9\u00b75 days for periods 1 and 2 respectively (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0\u00b705). There were no significant differences in potential confounders such as transfusion volume (\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u00b706), number of units transfused, ferritin or transfusion interval.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Discussion:<\/jats:bold>\n                    Use of fresh blood produced significantly higher pre\u2010transfusion Hb, giving credence to UK consensus. Lesser volumes of fresh blood appeared to achieve the target pre\u2010transfusion Hb, which may translate to reduced iron overload and chelation costs. Whether the assumption that the use of blood less than 7 days old in these patients would result in greater benefit requires further study.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-3148.2011.01102.x","type":"journal-article","created":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T04:35:51Z","timestamp":1315197351000},"page":"417-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fresh blood for transfusion in adults with beta thalassaemia"],"prefix":"10.1111","volume":"21","author":[{"given":"N. R.","family":"Priddee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Pendry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. E.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1994.34694295068.x"},{"key":"e_1_2_7_3_1","unstructured":"Kleinman S.(2010)Use of Red Blood Cells for Transfusion.URLhttp:\/\/www.uptodate.com(Accessed 10 January 2011)."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01734.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb07396.x"},{"key":"e_1_2_7_6_1","unstructured":"SaBTO(2009a)Advisory Committee on Safety of Blood Tissuesand Organs.Sixth Meeting Summary. URLhttp:\/\/www.dh.gov.uk\/prod_consum_dh\/groups\/dh_digitalassets\/@dh\/@ab\/documents\/digitalasset\/dh_100310.pdf(Accessed 09 June 2011)."},{"key":"e_1_2_7_7_1","unstructured":"SaBTO(2009b)Advisory Committee on Safety of Blood Tissues and Organs.Eighth Meeting Summary. URLhttp:\/\/www.dh.gov.uk\/prod_consum_dh\/groups\/dh_digitalassets\/@dh\/@ab\/documents\/digitalasset\/dh_108860.pdf(Accessed 09 June 2011)."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1996.tb01330.x"},{"key":"e_1_2_7_9_1","first-page":"15.","volume-title":"Standards for the Clinical Care of Children and Adults with thalassaemia in the UK","author":"UK Thalassaemia Society","year":"2008"},{"key":"e_1_2_7_10_1","first-page":"29.","volume-title":"Standards for the Clinical Care of Children and Adults with thalassaemia in the UK","author":"UK Thalassaemia Society","year":"2008"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3148.2011.01102.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3148.2011.01102.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:29:11Z","timestamp":1698730151000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3148.2011.01102.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,5]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1111\/j.1365-3148.2011.01102.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3148.2011.01102.x","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,5]]},"assertion":[{"value":"2011-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}