{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:28:50Z","timestamp":1788265730589,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T00:00:00Z","timestamp":1315526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p><jats:bold>Background\/Aims:<\/jats:bold> Prophylactic anti\u2010D given during pregnancy can be detected in current indirect antiglobulin tests (IAT). Using this to measure the persistence of prophylactic anti\u2010D, this study set out to determine whether there is an association between anti\u2010D detectable at delivery and the RhD status of the foetus and\/or the duration of the pregnancy post the standard 28 week dose of routine antenatal anti\u2010D prophylaxis (RAADP). The study also investigated the detection rates of anti\u2010D at delivery when given in a two dose regime or a one dose regime.<\/jats:p><jats:p><jats:bold>Method:<\/jats:bold> All IAT screening was undertaken using fully automated Diamed gel technology. The results from 407 women were included in the two dose regime study, and 157 in the one dose regime study.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> 160\/407 (39%) women receiving one dose of prophylactic anti\u2010D had no detectable anti\u2010D at delivery. 123\/157 (78%) women on the one dose regime had no detectable anti\u2010D at delivery. No association was found between detectable anti\u2010D at delivery and the RhD status of the infant in either study arm. A strong association was found between detectable anti\u2010D Ig at delivery and the duration of the pregnancy post the 28 week dose in each study arm.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our data show that neither the two dose nor the one dose regime appear to provide adequate cover at delivery for a large percentage of pregnant women. This appears to be associated with the duration of the pregnancy past the 28 week dose but not associated with the RhD status of the foetus.<\/jats:p>","DOI":"10.1111\/j.1365-3148.2011.01106.x","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T19:47:57Z","timestamp":1315597677000},"page":"421-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Routine antenatal anti\u2010D prophylaxis \u2013 is the protection adequate?"],"prefix":"10.1111","volume":"21","author":[{"given":"J.","family":"Davies","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Chant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02158.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.1996.d01-518.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","unstructured":"Chilcott J. Lloyd Jones M. Wright J. Forman K. Wray J.&Beverley C.(2002)A review of the clinical effectiveness and cost effectiveness of routine ant\u2010D prophylaxis for pregnant women who are rhesus (RhD) negative.On behalf of the National Institute of Clinical Excellence.","DOI":"10.3310\/hta7040"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"621.","DOI":"10.1182\/blood.V23.5.621.621","article-title":"Mechanisma of iso\u2010immunization. I. 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Nosenzo C.et al.(1964)Patterns of Rh\u2010immunization.Commun 10th Congr Int Soc Haematol Stockholm."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08304.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00988.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00789.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04442-1"},{"key":"e_1_2_7_17_1","unstructured":"NICE.(2002)Guidance on the use of routine antenatal anti\u2010D prophylaxis for RhD negative women."},{"key":"e_1_2_7_18_1","unstructured":"NICE.(2008)Routine antenatal anti\u2010D prophylaxis for women who are rhesus D negative."},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.5858\/133.3.465","article-title":"Inaccurate doses of Rh immune glogulin after Rh\u2010incompatible fetomaternal hemorrhage.","volume":"133","author":"Ramsey G.","year":"2009","journal-title":"Archives of Pathology and Laboratory Medicine"},{"key":"e_1_2_7_20_1","first-page":"1145","article-title":"Is a third\u2010trimester antibody screen for Rh+ women necessary?","volume":"5","author":"Rothenburg J.M.","year":"1999","journal-title":"American Journal of Managed Care"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(02)00310-X"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6689.1671"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.1992.tb00142.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90232-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91068-N"},{"key":"e_1_2_7_26_1","first-page":"59.","article-title":"Routine antenatal anti\u2010D prophylaxis (RAADP); An unusual phenomenon?","volume":"17","author":"Young A.","year":"2007","journal-title":"Transfusion Medicine"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3148.2011.01106.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3148.2011.01106.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T09:29:27Z","timestamp":1698744567000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3148.2011.01106.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,9]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1111\/j.1365-3148.2011.01106.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3148.2011.01106.x","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,9]]},"assertion":[{"value":"2011-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}