{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:54:44Z","timestamp":1789419284586,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,11]],"date-time":"2011-12-11T00:00:00Z","timestamp":1323561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> To evaluate the association between perioperative blood transfusion on the recurrence and survival of patient with advanced ovarian cancer.<\/jats:p><jats:p><jats:bold>Background:<\/jats:bold> Cytoreductive surgery for ovarian cancer can be an extensive procedure often requiring allogeneic blood transfusions. Blood transfusions can have detrimental effects on immune function which can lead to a decrease in the organism ability to detect and destroy metastasis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study was a retrospective cohort investigation. Patients with advanced ovarian cancer (stage III) undergoing cytoreductive surgery were stratified by the need for perioperative blood transfusion. Allogeneic transfusions were non\u2010leucodepleted. Primary outcome included time to recurrence and survival. Data were extracted from the gynaecology oncology database at Northwestern University. Times to event outcomes were evaluated by constructing Kaplan\u2013Meyer curves and Cox regression.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The charts of 136 subjects were evaluated. Seventy\u2010six received blood transfusion. Median [95% confidence interval (CI)] time to recurrence for the non\u2010transfusion group was longer, i.e. 17 (6\u201327) months, compared to 11 (8\u201314) months for the transfused group (<jats:italic>P<\/jats:italic> = 0\u00b703). Median (95% CI) survival following surgery was longer in the non\u2010transfused group, i.e. 58 (43\u201373) months, compared to 36 (28\u201344) months for the transfused group (<jats:italic>P<\/jats:italic> = 0\u00b704). Cox regression showed that transfused subjects had shorter median times to recurrence and mortality after adjusting for age and tumour grade.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> There is an association between ovarian cancer recurrence and allogeneic perioperative blood transfusion in patients with advanced ovarian cancer undergoing cytoreductive surgery. These findings may have important implications in the perioperative management of those patients.<\/jats:p>","DOI":"10.1111\/j.1365-3148.2011.01122.x","type":"journal-article","created":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T05:45:06Z","timestamp":1323668706000},"page":"97-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["The association between allogeneic perioperative blood transfusion on tumour recurrence and survival in patients with advanced ovarian cancer"],"prefix":"10.1111","volume":"22","author":[{"suffix":"Jr.","given":"G. S.","family":"De Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Schink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Buoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C.","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005033.pub2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820139509062781"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78209-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1182\/blood.V84.1.344.344","article-title":"Growth enhancement of established tumors by allogeneic blood transfusion in experimental animals and its amelioration by leukodepletion: the importance of the timing of the leukodepletion.","volume":"84","author":"Bordin J.O.","year":"1994","journal-title":"Blood"},{"key":"e_1_2_7_6_1","first-page":"145","volume-title":"Immunomodulatory Effects of Blood Transfusion","author":"Brand A.","year":"1999"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e318217aada"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072739"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850315)55:6<1195::AID-CNCR2820550610>3.0.CO;2-H"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(88)80190-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(03)90118-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.09.028"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(85)80047-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1182\/blood.V88.11.4375.bloodjournal88114375","article-title":"Induction of humoral immune tolerance to major histocompatibility complex antigens by transfusions of UVB\u2010irradiated leukocytes.","volume":"88","author":"Kao K.J.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1990.01870030068011"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6636"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(97)80047-7"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-009-0973-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-002-0404-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860701441830"},{"key":"e_1_2_7_22_1","first-page":"225","article-title":"Perioperative blood transfusion has prognostic significance for breast cancer.","volume":"97","author":"Tartter P.I.","year":"1985","journal-title":"Surgery"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2007.07.003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.2517"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.8.1348"},{"key":"e_1_2_7_26_1","first-page":"303","article-title":"Perioperative blood transfusion promotes recurrence of hepatocellular carcinoma after hepatectomy.","volume":"115","author":"Yamamoto J.","year":"1994","journal-title":"Surgery"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.11.033"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3148.2011.01122.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3148.2011.01122.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T20:27:40Z","timestamp":1697660860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3148.2011.01122.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,11]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1365-3148.2011.01122.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3148.2011.01122.x","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,11]]},"assertion":[{"value":"2011-12-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}