{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:42:16Z","timestamp":1790174536636,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,30]],"date-time":"2011-12-30T00:00:00Z","timestamp":1325203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:bold>Aim\/Objective:<\/jats:bold> Iran is located on the Mediterranean belt and has high prevalence of thalassaemia. Deferoxamine therapy requires burdensome hours of daily infusion several times a week.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We studied 510 thalassaemia major patients referring to thalassaemia tertiary care centre for compliance of deferoxamine and also assessed various reasons for non\u2010compliance. A questionnaire was developed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Our study showed that 418 (82%) subjects were adherent to deferoxamine therapy. Females were more adherent to the chelation therapy. Among patients whose age was \u226412 years, 90\u00b74% showed drug compliance compared with 80\u00b73% in patients aged &gt;12 years (<jats:italic>P<\/jats:italic> = 0\u00b703). The most frequently reported reason for poor compliance was pain (38%).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> High percentage of patients had adherence to iron chelation, which is in contrast to previous studies. This may be attributed to the vigorous efforts of governmental and non\u2010governmental organisations in educating patients and provision of free drug and equipment in the past few years. The results were satisfying but still more is to be done to increase drug adherence and to minimise reasons causing poor compliance.<\/jats:p>","DOI":"10.1111\/j.1365-3148.2011.01130.x","type":"journal-article","created":{"date-parts":[[2011,12,30]],"date-time":"2011-12-30T06:35:58Z","timestamp":1325226958000},"page":"104-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Compliance of deferoxamine injection in beta\u2010thalassaemia major patients in Iran"],"prefix":"10.1111","volume":"22","author":[{"given":"M.","family":"Rashid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280000251"},{"key":"e_1_2_7_3_1","first-page":"127","article-title":"Thalassemia major and consanguinity in Shiraz city, Iran.","volume":"21","author":"Asadi\u2010Pooya A.A.","year":"2004","journal-title":"Turkish Journal of Haematology"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(89)90089-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2008.tb01523.x"},{"key":"e_1_2_7_6_1","first-page":"46","article-title":"Iron deficiency and overload.","volume":"1","author":"Beutler E.","year":"2003","journal-title":"Hematology\/American Society of Hematology Education Program"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2002001100009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409013310902"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1043828"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050241"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2004.1.14"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-198908000-00010"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3167"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01416.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1182\/blood.V76.3.435.435","article-title":"Treatment of Cooley's anemia.","volume":"76","author":"Fosburg M.T.","year":"1990","journal-title":"Blood"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000203853"},{"key":"e_1_2_7_18_1","first-page":"27","article-title":"Thalassemia in Iran; an overview.","volume":"1","author":"Habibzadeh F.","year":"1998","journal-title":"Archives of Iranian Medicine"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1979.tb03719.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1081\/HEM-100105221"},{"key":"e_1_2_7_21_1","first-page":"878","volume-title":"Nathan and Oski's Hematology of Infancy and Childhood","author":"Orkin S.H.","year":"2003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1345.065"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01398.x"},{"key":"e_1_2_7_24_1","first-page":"36","article-title":"Compliance with chronic illness regimens: school aged children and adolescents.","volume":"4","author":"Pidgeon V.","year":"1989","journal-title":"Journal of Pediatric Nursing"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1993.tb04722.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802160834"},{"key":"e_1_2_7_27_1","first-page":"118","volume-title":"Manual of Clinical Hematology","author":"Schnall S.F.","year":"1998"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-2-3"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3148.2011.01130.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3148.2011.01130.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T20:27:21Z","timestamp":1697660841000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3148.2011.01130.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,30]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1365-3148.2011.01130.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3148.2011.01130.x","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,30]]},"assertion":[{"value":"2011-12-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}