{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:56:10Z","timestamp":1787014570263,"version":"build-2736575974"},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,6,8]],"date-time":"2004-06-08T00:00:00Z","timestamp":1086652800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2004,6]]},"abstract":"Summary<\/jats:title>\n \n Background\u2002<\/jats:bold>\n In the tropical north of the Northern Territory, Australia, 25\u201350 patients are admitted to Royal Darwin Hospital (RDH) each year with\n Burkholderia pseudomallei<\/jats:italic>\n infection, or melioidosis. Treatment consists of initial intensive therapy with 2\u20134\u2003weeks of intravenous antibiotics. Clinical improvement may occur early and patients often prefer to be managed out of hospital in the Hospital in the Home (HITH).\n <\/jats:p>\n \n Objectives\u2002<\/jats:bold>\n To evaluate safety and efficacy of HITH management of patients with melioidosis.\n <\/jats:p>\n \n Methods\u2002<\/jats:bold>\n A prospective observational study of our standard management which consists of 24\u2003h infusions of ceftazidime infused through a peripherally inserted central catheter (PICC) line, plus oral sulphamethoxazole trimethoprim. Treatment is administered in the home, which may be in Darwin, regional areas or remote communities, or in a self\u2010care unit located in the hospital grounds.\n <\/jats:p>\n \n Results\u2002<\/jats:bold>\n From February 1998 to December 2001 150 patients were admitted to RDH with culture confirmed\n B. pseudomallei<\/jats:italic>\n infection. Of these, 73 patients were treated with 24\u2003h infusions of ceftazidime, of which 70 patients were managed by HITH. Complications of treatment include a PICC line complication rate of 10.6\/1000\u2003days\n in situ<\/jats:italic>\n . Nine patients had relapse or recrudescence of disease, nearly all as a result of poor adherence to subsequent oral eradication therapy, these patients were all re\u2010treated successfully. One patient remains infected with\n B. pseudomallei<\/jats:italic>\n .\n <\/jats:p>\n \n Conclusion\u2002<\/jats:bold>\n This clinical outcome study suggests that out of hospital management of melioidosis with 24\u2003h infusions of ceftazidime via a PICC line is safe and effective.\n <\/jats:p>","DOI":"10.1111\/j.1365-3156.2004.01244.x","type":"journal-article","created":{"date-parts":[[2004,12,29]],"date-time":"2004-12-29T13:54:30Z","timestamp":1104328470000},"page":"715-717","source":"Crossref","is-referenced-by-count":22,"title":["Out of hospital treatment of patients with melioidosis using ceftazidime in 24\u2003h elastomeric infusors, via peripherally inserted central catheters"],"prefix":"10.1111","volume":"9","author":[{"given":"Sarah","family":"Huffam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan P.","family":"Jacups","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulene","family":"Kittler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart J.","family":"Currie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,6,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2000.00179.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/318116"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/501917"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0203000103"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61865-X"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.9.2643-2647.2001"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/ajhp\/55.7.683","article-title":"Drug stability and pyridine generation in ceftazidime injection stored in an elastomeric infusion device","volume":"55","author":"Stendal TL","year":"1998","journal-title":"American Journal of Health-System Pharmacy"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.8.2327-2332.2002"}],"container-title":["Tropical Medicine & International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3156.2004.01244.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3156.2004.01244.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T10:41:04Z","timestamp":1696934464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3156.2004.01244.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1111\/j.1365-3156.2004.01244.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3156.2004.01244.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1019927.231462","asserted-by":"object"}]},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}