{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:09:33Z","timestamp":1778285373353,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,12]],"date-time":"2005-01-12T00:00:00Z","timestamp":1105488000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This paper presents health outcomes and associated socioeconomic factors of 41 children admitted to a tertiary care institution in south\u2010east Nigeria with Burkitt's lymphoma (BL) between 1987 and 2004. BL responds well to chemotherapy and does not pose a significant threat to health in industrialized nations. However, in resource\u2010poor settings where it is endemic, socioeconomic factors significantly affect access to care for affected children, making this readily treatable condition a cause of considerable distress and early death in affected children. Half of the children reported in this paper presented with late stage disease. Although laboratory facilities were available, they were not accessible to all the children. Nearly a quarter of parents of these children could not afford the cost of confirmatory tests, and about a fifth (<jats:italic>n<\/jats:italic>\u2003=\u20038; 19.5%) of the children received no chemotherapy because of their parents\u2019 inability to pay. Only 21 of 41 children (51.2%) remained on treatment long enough (at least 12\u2003weeks) to enable them to be confirmed either as short\u2010term cure (<jats:italic>n<\/jats:italic>\u2003=\u20039; 64.3%), or as early relapse (<jats:italic>n<\/jats:italic>\u2003=\u20032; 4.9%). Owing to financial constraint, 13 of the parents (31.7%) withdrew their children against medical advice (<jats:italic>n<\/jats:italic>\u2003=\u20037; 17.1%) or left the hospital (<jats:italic>n<\/jats:italic>\u2003=\u20036; 14.6%). To address the challenge posed by these factors, we call for the establishment of a regional BL programme in Africa to help establish a critical mass of resources (human and material) to facilitate the development of an effective and accessible control programme in the region.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2004.01348.x","type":"journal-article","created":{"date-parts":[[2005,1,12]],"date-time":"2005-01-12T11:45:41Z","timestamp":1105530341000},"page":"92-98","source":"Crossref","is-referenced-by-count":55,"title":["Socioeconomic constraints to effective management of Burkitt's lymphoma in south\u2010eastern Nigeria"],"prefix":"10.1111","volume":"10","author":[{"given":"M. M.","family":"Meremikwu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Ehiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. G.","family":"Nkanga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. E.","family":"Udoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. F.","family":"Ikpatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. O.","family":"Alaje","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-1971(92)90034-3"},{"key":"e_1_2_12_3_1","first-page":"1","article-title":"Observations on some aetiological factors in Burkitt's lymphoma","volume":"12","author":"Aderele WI","year":"1983","journal-title":"African Journal of Medicine and Medical Science"},{"key":"e_1_2_12_4_1","first-page":"362","article-title":"Epstein\u2010Barr virus\u2010associated lymphoproliferative disorders","volume":"7","author":"Ambinder RF","year":"2003","journal-title":"Reviews in Clinical and Experimental Hematology"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004619704"},{"key":"e_1_2_12_6_1","first-page":"11","article-title":"The beginnings of the Burkitt's lymphoma story","volume":"60","author":"Burkitt DP","year":"1985","journal-title":"IARC Scientific Publications"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2003.97"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199409049685"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90055-1"},{"key":"e_1_2_12_10_1","first-page":"255","article-title":"Burkitt's lymphoma in Ethiopian Children","volume":"42","author":"Daniel E","year":"1990","journal-title":"Tropical and Geographical Medicine"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4103\/1117-1936.171286","article-title":"Factors determining the outcome of management of patients with Burkitt's lymphoma at the University College Hospital Ibadan, Nigeria \u2013 an eleven year review","volume":"9","author":"Fasola FA","year":"2002","journal-title":"The Nigerian Postgraduate Medical Journal"},{"key":"e_1_2_12_12_1","first-page":"29","article-title":"A re\u2010appraisal of the management of common childhood abdominal malignancies in Ibadan, Nigerian","volume":"11","author":"Johnson AOK","year":"1984","journal-title":"Journal of Pediatrics"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199122000-00019"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4269\/ajtmh.1996.54.343","article-title":"The pattern of pediatric solid malignant tumors in Western Kenya, East Africa 1976\u20131994: an analysis based on histopathological study","volume":"54","author":"Makata AM","year":"1996","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_12_15_1","first-page":"6","article-title":"User fees and management of Burkitt's lymphoma in Nigerian children: making a bad case worse","volume":"5","author":"Meremikwu M","year":"1997","journal-title":"Bulletin of Tropical Medicine and International Health"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(01)90348-7"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605093341906"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-9276-3-6"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199706)182:2<125::AID-PATH843>3.0.CO;2-9"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10372"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3156.2004.01348.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3156.2004.01348.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:12:38Z","timestamp":1696921958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3156.2004.01348.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1111\/j.1365-3156.2004.01348.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3156.2004.01348.x","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}