{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:47:36Z","timestamp":1790171256612,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,12]],"date-time":"2005-01-12T00:00:00Z","timestamp":1105488000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>New drug combinations against falciparum malaria which are both effective and affordable for Sub\u2010Saharan African populations are urgently needed. The combination of the well\u2010known drugs chloroquine (CQ) and methylene blue (MB) is such a promising new regimen. However, there is some concern that MB could cause development of haemolysis in patients with glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency, a condition which is prevalent in malaria\u2010endemic regions. Against this background, 74 G6PD\u2010deficient but otherwise healthy adult men were given a 3\u2010day oral regimen of a total of 1500\u2003mg CQ and 780\u2003mg MB in the District Hospital of Nouna in north\u2010western Burkina Faso. Haemolysis did not occur, haemoglobin levels remained stable or even rose in the study participants, and the drug regimen was well tolerated. Therefore, standard dosages of MB appear to be safe in G6PD\u2010deficient African populations with predominantly class III G6PD deficiency.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2004.01356.x","type":"journal-article","created":{"date-parts":[[2005,1,12]],"date-time":"2005-01-12T11:45:41Z","timestamp":1105530341000},"page":"32-38","source":"Crossref","is-referenced-by-count":49,"title":["Safety of the combination of chloroquine and methylene blue in healthy adult men with G6PD deficiency from rural Burkina 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