{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:46:17Z","timestamp":1769147177398,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T00:00:00Z","timestamp":1106870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To compare a topical quinolone antibiotic (ciprofloxacin) with a cheaper topical antiseptic (boric acid) for treating chronic suppurative otitis media in children.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Randomized controlled trial.<\/jats:p><jats:p><jats:bold>Setting and participants\u2002<\/jats:bold> A total of 427 children with chronic suppurative otitis media enrolled from 141 schools following screening of 39\u2003841 schoolchildren in Kenya.<\/jats:p><jats:p><jats:bold>Intervention\u2002<\/jats:bold> Topical ciprofloxacin (<jats:italic>n<\/jats:italic>\u2003=\u2003216) or boric acid in alcohol (<jats:italic>n<\/jats:italic>\u2003=\u2003211); child\u2010to\u2010child treatment twice daily for 2\u2003weeks.<\/jats:p><jats:p><jats:bold>Main outcome measures\u2002<\/jats:bold> Resolution of discharge (at 2\u2003weeks for primary outcome), healing of the tympanic membrane, and change in hearing threshold from baseline, all at 2 and 4\u2003weeks.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> At 2\u2003weeks, discharge was resolved in 123 of 207 (59%) children given ciprofloxacin, and in 65 of 204 (32%) given boric acid (relative risk 1.86; 95% CI 1.48\u20132.35; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). This effect was also significant at 4\u2003weeks, and ciprofloxacin was associated with better hearing at both visits. No difference with respect to tympanic membrane healing was detected. There were significantly fewer adverse events of ear pain, irritation, and bleeding on mopping with ciprofloxacin than boric acid.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Ciprofloxacin performed better than boric acid and alcohol for treating chronic suppurative otitis media in children in Kenya.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2004.01368.x","type":"journal-article","created":{"date-parts":[[2005,1,29]],"date-time":"2005-01-29T08:50:25Z","timestamp":1106988625000},"page":"190-197","source":"Crossref","is-referenced-by-count":34,"title":["Topical quinolone <i>vs<\/i>. antiseptic for treating chronic suppurative otitis media: a randomized controlled trial"],"prefix":"10.1111","volume":"10","author":[{"given":"Carolyn","family":"Macfadyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrol","family":"Gamble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Garner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Macharia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Mackenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Mugwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Oburra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennedy","family":"Otwombe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,28]]},"reference":[{"key":"e_1_2_17_2_1","first-page":"710","article-title":"Chronic suppurative otitis media","volume":"12","author":"Acuin J","year":"2004","journal-title":"Clinical Evidence"},{"key":"e_1_2_17_3_1","volume-title":"The Cochrane Library, Issue 2, 2004","author":"Acuin J","year":"2004"},{"key":"e_1_2_17_4_1","first-page":"222","volume-title":"Deafness","author":"Ballantyne J","year":"1984"},{"key":"e_1_2_17_5_1","first-page":"126","article-title":"Otitis media in developing countries","volume":"96","author":"Berman S","year":"1995","journal-title":"Pediatrics"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5541011202"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880040050009"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900100031003"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(95)01209-5"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.10.1098"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00271-1"},{"key":"e_1_2_17_12_1","unstructured":"Ministry of Planning and National Development(2004)The Central Bureau of Statistics.Ministry of Planning and National Development Kenya.http:\/\/www.cbs.go.ke(last accessed 9 February 2004)."},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(01)00552-3"},{"key":"e_1_2_17_14_1","unstructured":"Office of the District Education Officer(2002)List of School Enrolment in February 2002.Provided by Zedekia Owira Inspector of Schools for Kisumu District Education Office Kisumu District."},{"key":"e_1_2_17_15_1","volume-title":"SAS Institute Inc","author":"SAS v8.2","year":"2001"},{"key":"e_1_2_17_16_1","first-page":"1133","article-title":"Randomised controlled trial of treatment of chronic suppurative otitis media in Kenyan schoolchildren","volume":"349","author":"Smith AW","year":"1996","journal-title":"Lancet"},{"key":"e_1_2_17_17_1","unstructured":"Standard Treatment for Common Illnesses of Children in Papua New Guinea(1993)A Manual For Nurses Health Extension Officers and Doctors. 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