{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:47:32Z","timestamp":1791085652693,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T00:00:00Z","timestamp":1125014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold> The Global Programme to Eliminate Lymphatic Filariasis recommends albendazole in combination with other antifilarial drugs. This systematic review examines albendazole in treatment and control of lymphatic filariasis.<\/jats:p><jats:p><jats:bold>Datasources\u2002<\/jats:bold> The Cochrane Controlled Trials Register, MEDLINE and EMBASE to April 2005; contacting experts, international organisations and drug manufacturers.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Randomised or quasi\u2010randomised controlled trials included; two reviewers independently assessed eligibility, quality, and extracted data. We calculated the relative risk of microfilaraemia (mf) prevalence using fixed effect, or random effects model in case of heterogeneity.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Six trials met inclusion criteria. Three trials compared albendazole with placebo: no effect was demonstrated on mf prevalence, but density was lower in one of the three studies at 6\u2003months. Three trials added albendazole to ivermectin, with no demonstrable effect; prevalence tended to be lower at 4\u20136\u2003months but not at 12\u2003months (4\u20136\u2003months; RR 0.49, 95% CI 0.18 to 1.39, <jats:italic>n<\/jats:italic>\u2003=\u2003255, 2 trials; 12\u2003months: RR 1.00, 95% CI 0.88 to 1.13, <jats:italic>n<\/jats:italic>\u2003=\u2003348, 2 trials). Mf density was significantly lower in two of the three trials; one of two trials measuring density at 12\u2003months showed a difference. Three trials added albendazole to diethylcarbamazine; two were small trials with no difference demonstrated; the third study tended to favour combination at 6\u2003months (RR\u2003=\u20030.62, 95% CI 0.32 to 1.21, <jats:italic>n<\/jats:italic>\u2003=\u2003491), with a significant difference for density.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The effect of albendazole against adult and larval filarial parasites, alone and in combination with other antifilarial drugs, deserves further rigorous research.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2005.01458.x","type":"journal-article","created":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T11:54:17Z","timestamp":1125057257000},"page":"818-825","source":"Crossref","is-referenced-by-count":44,"title":["Albendazole for the control and elimination of lymphatic filariasis: systematic review"],"prefix":"10.1111","volume":"10","author":[{"given":"Julia","family":"Critchley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Addiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Ejere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrol","family":"Gamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Garner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hellen","family":"Gelband","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the International Filariasis Review Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,8,26]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Global Programme to Eliminate Lymphatic Filariasis"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02231-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.60.479"},{"key":"e_1_2_5_5_1","volume-title":"The Cochrane Database of Systematic Reviews 2000","author":"Dickson R","year":"2003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(00)90278-5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4269\/ajtmh.2005.73.115","article-title":"Tolerance and efficacy of combined Diethycarbamazine and albendazole for treatment of Wuchereria bancrofti and intestinal helminth infections in Haitian children","volume":"73","author":"Fox LM","year":"2005","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.6.2.179"},{"key":"e_1_2_5_9_1","volume-title":"The Cochrane Database of Systematic Reviews 2004","author":"International Filariasis Review Group (David Addiss, Julia Critchley, Henry Ejere, Paul Garner, Hellen Gelband, Carrol Gamble)","year":"2005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(98)90972-5"},{"key":"e_1_2_5_11_1","first-page":"19","article-title":"Treatment of bancroftian filariasis with albendazole: evaluation of efficacy and adverse reactions","volume":"10","author":"Jayakody RL","year":"1993","journal-title":"Tropical Biomedicine"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7303.42"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(03)00044-0"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(99)01486-6"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2883-1-1"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2003.12.005"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3156.2005.01458.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3156.2005.01458.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T23:56:58Z","timestamp":1697241418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3156.2005.01458.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,26]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1111\/j.1365-3156.2005.01458.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3156.2005.01458.x","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,26]]}}}