{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T11:30:38Z","timestamp":1791718238059,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T00:00:00Z","timestamp":1125014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> The aim of the study was to assess the effects of micronutrient supplementation on culture conversion in tuberculosis (TB) patients.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> The study was a randomized, double\u2010blind placebo\u2010controlled 2\u2003\u00d7\u20032 trial of zinc and multi\u2010micronutrient (MMN) supplementation in pulmonary TB patients in Tanzania.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 499 pulmonary TB patients were included in the trial after being confirmed sputum\u2010positive by microscopy or culture. At 8\u2003weeks, 25% were sputum\u2010smear positive but only 11% were culture\u2010positive (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). No significant differences were observed in culture conversion rate among those allocated to MMN or placebo (89.5 <jats:italic>vs<\/jats:italic>. 86.2%, <jats:italic>P<\/jats:italic>\u2003=\u20030.29) at 8\u2003weeks, although at week 4 those allocated to MMN had a slightly reduced culture conversion rate (42.8 <jats:italic>vs<\/jats:italic>. 52.8%, <jats:italic>P<\/jats:italic>\u2003=\u20030.058). Zinc had no effects on culture conversion. MMN increased weight gain by 0.78\u2003kg [95% confidence interval (CI): 0.12\u20131.43] at week 8, while zinc supplementation had no effect. The effects of MMN and zinc did not interact and neither MMN nor zinc interacted with human immunodeficiency virus status, sex and culture\u2010intensity at baseline.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Neither zinc nor MMN supplementation had significant effects on culture conversion, but MMN supplementation increased weight gain in TB patients.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2005.01463.x","type":"journal-article","created":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T15:54:17Z","timestamp":1125071657000},"page":"826-832","source":"Crossref","is-referenced-by-count":46,"title":["The effect of micronutrient supplementation on treatment outcome in patients with pulmonary tuberculosis: a randomized controlled trial in Mwanza, Tanzania"],"prefix":"10.1111","volume":"10","author":[{"given":"Nyagosya","family":"Range","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5se B.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Magnussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apolinary","family":"Mugomela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Friis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,8,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.4.958"},{"key":"e_1_2_7_3_1","first-page":"307","article-title":"Tuberculosis chemotherapy and sputum conversion among HIV\u2010seropositive and HIV\u2010seronegative patients in south\u2010eastern Uganda","volume":"76","author":"Bwire R","year":"1999","journal-title":"East African Medical Journal"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/514132"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040541"},{"key":"e_1_2_7_6_1","first-page":"263","article-title":"A comparative study on the reliability of the fluorescence microscopy and Ziehl\u2013Neelsen method in the diagnosis of pulmonary tuberculosis","volume":"70","author":"Githui W","year":"1993","journal-title":"East African Medical Journal"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555818357.ch7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(00)90335-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.12.2953"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/75.4.720"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199510000-00011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1301\/nr.2003.marr.81-90"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.10.1110"},{"key":"e_1_2_7_14_1","first-page":"804","article-title":"Vitamin A status of patients presenting with pulmonary tuberculosis and asymptomatic HIV\u2010infected individuals, Dar es Salaam, Tanzania","volume":"7","author":"Mugusi FM","year":"2003","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"e_1_2_7_15_1","first-page":"909","article-title":"Bacteriological follow\u2010up of tuberculosis treatment: a comparative study of smear microscopy and culture results at the second month of treatment","volume":"6","author":"Ramarokoto H","year":"2002","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"e_1_2_7_16_1","first-page":"719","article-title":"Plasma zinc status in Indian childhood tuberculosis: impact of antituberculosis therapy","volume":"2","author":"Ray M","year":"1998","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"e_1_2_7_17_1","volume-title":"The public health service national tuberculosis reference laboratory and the national laboratory network. Minimum requirements, role and operation in a low\u2010income country, International Union Against Tuberculosis and Lung Disease","author":"Rieder HL","year":"1998"},{"key":"e_1_2_7_18_1","first-page":"771","article-title":"Serum vitamin A levels during tuberculosis and human immunodeficiency virus infection","volume":"2","author":"Rwangabwoba JM","year":"1998","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199101313240503"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/513772"},{"key":"e_1_2_7_21_1","volume-title":"Treatment of Tuberculosis: Guidelines for National Programmes","author":"World Health Organization","year":"2003"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3156.2005.01463.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3156.2005.01463.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T03:56:12Z","timestamp":1697255772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3156.2005.01463.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,26]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1111\/j.1365-3156.2005.01463.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3156.2005.01463.x","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,26]]}}}