{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:06:18Z","timestamp":1761487578831},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T00:00:00Z","timestamp":1145923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To determine the efficacies of combinations of ivermectin or diethylcarbamazine and albendazole, which are recommended for use in mass treatment programmes against lymphatic filariasis.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> Review of published trends in microfilarial (mf) intensities after treatment with these combination therapies. By fitting a mathematical model of treatment effects to the trial data, we quantified the efficacy of treatment, distinguishing between the killing of mf (mf loss) and a reduction in mf production by adult worms (worm\u2010productivity loss). After diethylcarbamazine\u2013albendazole treatment mf density dropped immediately, then slowly but steadily decreased further (four trials). After ivermectin\u2013albendazole treatment, mf densities immediately dropped to near\u2010zero levels, followed by a small increase (five trials). For diethylcarbamazine\u2013albendazole treatment the average mf loss was approximately 83% (ranging from 54% to 100% in the different studies) and worm\u2010productivity loss was 100% (in all studies). For ivermectin\u2013albendazole treatment, average mf loss was 100% (ranging from 98% to 100%) and worm productivity loss was 96% (ranging from 83% to 100%). The effects were dose\u2010dependent. Sensitivity analysis showed that the estimates did not depend on assumptions on worm lifespan or premature period and little on assumptions on mf lifespan.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The two therapies differ with respect to their direct effect on mf, but both are highly effective against adult worms. If mass treatment with these combination therapies achieves high coverage, they can have a large impact on lymphatic filariasis transmission.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2006.01606.x","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T17:08:31Z","timestamp":1145984911000},"page":"718-728","source":"Crossref","is-referenced-by-count":23,"title":["Model\u2010based analysis of trial data: microfilaria and worm\u2010productivity loss after diethylcarbamazine\u2013albendazole or ivermectin\u2013albendazole combination therapy against <i>Wuchereria bancrofti<\/i>"],"prefix":"10.1111","volume":"11","author":[{"given":"Marlieke E. 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