{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:13:08Z","timestamp":1760119988581},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,6,2]],"date-time":"2006-06-02T00:00:00Z","timestamp":1149206400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>As part of the Global Programme for Elimination of Lymphatic Filariasis (GPELF), India is implementing mass drug administration (MDA) with annual single dose of diethylcarbamazine (DEC) with and without albendazole (ALB). The impact of MDAs on filarial infections and soil\u2010transmitted helminth (STH) infections was assessed during a 3\u2010year period in two communities, one with DEC\u2003+\u2003ALB and the other with DEC alone. Prior to each MDA (during 2001, 2002 and 2003), filarial indices (microfilaraemia and antigenaemia) were assessed from blood samples of 450\u2013650 persons aged 2\u201325\u2003years and STH infections in stool samples (Kato\u2013Katz method) from 325 to 500 children aged 9\u201310\u2003years. Mosquitoes resting indoors were collected to determine the filarial infection status. The microfilaraemia prevalence decreased significantly (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) in both arms, with the highest decline in the DEC\u2003+\u2003ALB arm (72%<jats:italic>vs.<\/jats:italic> 51%). Decline in micrefilaria intensity was also higher in the DEC\u2003+\u2003ALB arm (81.4%<jats:italic>vs.<\/jats:italic> 48.5%). In this arm alone, the antigenaemia prevalence was reduced significantly (62%; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). The reduction in STH prevalence was lower in the DEC alone arm (6.5%; NS) than in the DEC\u2003+\u2003ALB arm (70.9%; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Also, the egg reduction in DEC alone arm was only half that of DEC\u2003+\u2003ALB arm (49%<jats:italic>vs.<\/jats:italic> 97%). Our community\u2010based follow\u2010up study showed higher and sustained benefits with regard to filarial and STH infections for the two\u2010drug arm over the DEC alone arm. The trends suggest that at least 10 MDAs may be necessary to achieve the goal of elimination.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2006.01625.x","type":"journal-article","created":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T21:43:09Z","timestamp":1149630189000},"page":"851-861","source":"Crossref","is-referenced-by-count":24,"title":["Community\u2010based study to assess the efficacy of DEC plus ALB against DEC alone on bancroftian filarial infection in endemic areas in Tamil Nadu, south India"],"prefix":"10.1111","volume":"11","author":[{"given":"R.","family":"Rajendran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. P.","family":"Sunish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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