{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T15:42:46Z","timestamp":1775490166779,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,7,4]],"date-time":"2006-07-04T00:00:00Z","timestamp":1151971200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Bioko is the only island known in the world with endemic onchocerciasis. The island's rural communities consist of villages and cocoa plantations inhabited by Bubi and Fang ethnic groups. The aim of this study was to evaluate the impact of 8\u2003years of vertical ivermectin distribution on the prevalence and intensity of <jats:italic>Onchocerca volvulus<\/jats:italic> infection in the rural population by means of pre\u2010 (1989) and post\u2010long term treatment (1998) epidemiological surveys. In both surveys, the entire population of 12 randomly selected communities (1723 and 1082 individuals) was examined. The mean ivermectin therapeutic coverage for the 8\u2003years was 53.2%. Iliac crest skin snips were used for differential diagnosis between <jats:italic>O. volvulus<\/jats:italic> and <jats:italic>Mansonella streptocerca<\/jats:italic>. The crude <jats:italic>O. volvulus<\/jats:italic> infection prevalence before ivermectin intervention was 74.5% (1284\/1723); after the intervention it was 38.4% (415\/1082). The Community Microfilarial Load (CMFL) before and after ivermectin intervention was 28.29 microfilariae\/snip <jats:italic>vs.<\/jats:italic> 2.32 microfilariae\/snip. The reduction in prevalence and CMFL after eight annual rounds of ivermectin treatment corroborates the drug microfilaricidal activity and good tolerability. In the pre\u2010treatment survey, the prevalence was higher in the Bubi group (77.1%, 1126\/1461); post\u2010treatment it was higher among the Fang (51.1%, 92\/180). The reduction in prevalence and intensity of <jats:italic>O. volvulus<\/jats:italic> infection differed between ethnic groups and communities.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2006.01650.x","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T00:51:46Z","timestamp":1152233506000},"page":"1082-1091","source":"Crossref","is-referenced-by-count":24,"title":["Reduction in the prevalence and intensity of infection in <i>Onchocerca volvulus<\/i> microfilariae according to ethnicity and community after 8\u2003years of ivermectin treatment on the island of Bioko, Equatorial Guinea"],"prefix":"10.1111","volume":"11","author":[{"given":"J.","family":"Mas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ascaso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Escaramis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Abellana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Duran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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