{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:35:45Z","timestamp":1791214545985,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,7,4]],"date-time":"2006-07-04T00:00:00Z","timestamp":1151971200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Intermittent preventive treatment, the administration of a full course of an anti\u2010malarial treatment to a population at risk at specified time points regardless of whether or not they are known to be infected, is now a recommended approach to the prevention of malaria in pregnancy and is being explored as a potential way of preventing malaria in infants. However, in many malaria endemic areas, the main burden of malaria is in older children and increasing use of insecticide treated bednets is likely to increase further the proportion of episodes of malaria that occur in older children. Recently, it has been shown in Senegal and in Mali that intermittent preventive treatment given to older children during the malaria transmission season can be remarkably effective in preventing malaria. This approach to malaria control is likely to be most effective in areas with a high level of malaria transmission concentrated in a short period of the year. However, several issues need to be addressed before intermittent preventive treatment in children can be advocated for use in malaria control programmes. These include: (1) determination of whether intermittent preventive treatment adds to the protection afforded by other control measures such as insecticide\u2010treated bednets; (2) whether an effective and sustainable delivery system can be found; (3) choice of drug to be used; (4) optimum timing of drug administration; (5) the requisite interval between treatments. The potential benefits of intermittent preventive treatment in children are substantial; more research is needed to determine if this is a practical approach to malaria control.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2006.01657.x","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T00:51:46Z","timestamp":1152233506000},"page":"983-991","source":"Crossref","is-referenced-by-count":93,"title":["Review: Intermittent preventive treatment \u2013 a new approach to the prevention of malaria in children in areas with seasonal malaria transmission"],"prefix":"10.1111","volume":"11","author":[{"given":"Brian","family":"Greenwood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,4]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"313","article-title":"Compliance with malaria chemoprophylaxis over a five year period among children in a rural area of The Gambia","volume":"93","author":"Allen SJ","year":"1990","journal-title":"Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(93)90174-O"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.331.7519.727"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68264-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/367986"},{"issue":"4","key":"e_1_2_8_7_1","first-page":"6","article-title":"Impact of intermittent preventive treatment with sulfadoxine\u2010pyrimethamine targeting the transmission season on the incidence of clinical malaria in children aged 6 months to 10 years in Kambila, Mali","volume":"71","author":"Dicko S","year":"2004","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyh259"},{"key":"e_1_2_8_9_1","first-page":"205","article-title":"Analysis of the effects of malaria chemoprophylaxis in children on haematological responses, morbidity and mortality","volume":"81","author":"Geerligs PDP","year":"2003","journal-title":"Bulletin of the World Health Organisation"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)02141-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4269\/ajtmh.2004.70.1","article-title":"The use of anti\u2010malarial drugs to prevent malaria in the population of malaria\u2010endemic areas","volume":"70","author":"Greenwood BM","year":"2004","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(95)90419-0"},{"key":"e_1_2_8_13_1","unstructured":"Intermittent Preventive Treatment in Malaria Consortium. 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