{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:17:18Z","timestamp":1793924238770,"version":"4.8.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To evaluate the recent WHO's ultrasonographic diagnostic staging system of schistosomal periportal thickening\/fibrosis and to assess intra\/inter\u2010observer variation associated with its use.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Local standard of portal branch wall thickness (PBWT) for height was established using 150 healthy subjects. Intra and inter\u2010observer variation in image pattern identification and PBWT measurements were assessed in 94 and 35 subjects, respectively, with differing stages of periportal thickening fibrosis. WHO's diagnostic criteria were evaluated in 2451 community members (1277 males, 1174 females; mean age 18.8\u2003years) with an overall <jats:italic>Schistosoma mansoni<\/jats:italic> prevalence estimate of 65.9%.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> There were no significant inter\/intra\u2010observer variations in image pattern identification and PBWT measurements. Based on Ethiopian PBWT\u2010for\u2010height standard, 128\/2451 (5.2%) had insipient, 46\/2451 (1.9%) had possible\/probable and 112\/2451 (4.6%) had definite\/advanced periportal thickening\/fibrosis. Comparable figures were obtained using the Senegalese PBWT\u2010for\u2010height standard and there was good agreement between Ethiopian and Senegalese healthy control\u2010based diagnostic criteria in classifying the 286 subjects into stages of periportal thickening\/fibrosis (<jats:italic>\u03ba<\/jats:italic>\u2003=\u20030.87, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> With further improvement, the WHO's ultrasonographic diagnostic criteria can be used in health institutions and community surveys. Image pattern based assessment is simple and more reproducible than PBWT based assessment of periportal thickening\/fibrosis. The latter is, however, more useful in clarifying the status of an individual with doubtful image pattern, and in monitoring post\u2010treatment outcome of periportal thickening\/fibrosis. Considering the comparability of PBWT\u2010for\u2010height standards, setting one international standard of PBWT\u2010for\u2010height is more practical than developing local standards for each endemic area.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2006.01665.x","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T13:11:56Z","timestamp":1152709916000},"page":"1286-1294","source":"Crossref","is-referenced-by-count":17,"title":["Large scale evaluation of WHO's ultrasonographic staging system of schistosomal periportal fibrosis in Ethiopia"],"prefix":"10.1111","volume":"11","author":[{"given":"Nega","family":"Berhe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonn T.","family":"Geitung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girmay","family":"Medhin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svein G.","family":"Gundersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1989.40.72"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(90)90388-U"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1992.46.403"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2004.06.011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1989.41.63"},{"key":"e_1_2_6_7_1","first-page":"245","article-title":"Ultrasound versus clinical examination as indication for Schistosoma mansoni associated morbidity in children","volume":"43","author":"Doehring\u2010Schwerdtfeger E","year":"1992","journal-title":"Tropical Medicine and Parasitology"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0001-706X(92)90022-P"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1996.55.290"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(88)90519-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1988.38.86"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1988.39.196"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1996.54.586"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1997.d01-269.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/319247"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2003.00994.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2004.06.009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761995000200004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1980.29.217"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/18.3.680"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(97)00112-5"},{"key":"e_1_2_6_22_1","unstructured":"WHO(2000). 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