{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:32:39Z","timestamp":1790271159556,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T00:00:00Z","timestamp":1158796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To assess the effect on birthweight of antenatal mebendazole plus iron <jats:italic>vs.<\/jats:italic> placebo plus iron in a highly hookworm\u2010endemic area.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Double\u2010blind, randomized controlled trial set in rural and peri\u2010urban communities in the Peruvian Amazon region. A total of 1042 second trimester pregnant women between the ages of 18 and 44\u2003years were recruited from April to November 2003, and followed to July 2004. Women were randomly assigned to receive either mebendazole (500\u2003mg single dose) plus iron supplements (60\u2003mg elemental iron daily) or placebo plus iron supplements. The primary outcome was mean infant birthweight and secondary measures included proportion of low birthweight babies and maternal anaemia.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The prevalence of hookworm infection was 47.5%. There were no differences between intervention groups in mean birthweight (3104\u2003g <jats:italic>vs.<\/jats:italic> 3090\u2003g, <jats:italic>P<\/jats:italic>\u2003=\u20030.629), proportion of low birthweight (&lt;2500\u2003g; 8.1%<jats:italic>vs.<\/jats:italic> 8.7%, <jats:italic>P<\/jats:italic>\u2003=\u20030.755) or maternal anaemia in the third trimester [33.0% (158\/479) <jats:italic>vs.<\/jats:italic> 32.3% (152\/471), <jats:italic>P<\/jats:italic>\u2003=\u20030.815]. However, the proportion of very low birthweight (&lt;1500\u2003g) was significantly lower in the mebendazole group [0% (0\/479) <jats:italic>vs.<\/jats:italic> 1.5% (7\/471), <jats:italic>P<\/jats:italic>\u2003=\u20030.007].<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> This trial provides additional evidence for the use of anthelmintics, over and above iron supplementation, within antenatal care programmes in hookworm\u2010endemic areas. Benefits of de\u2010worming may be higher in countries not having an antenatal iron supplementation programme or where intensity of hookworm infections is higher.<\/jats:p><jats:p><jats:bold>Keywords<\/jats:bold> mebendazole , pregnant women , hookworm , birthweight , anaemia , randomized\u2010controlled trial<\/jats:p>","DOI":"10.1111\/j.1365-3156.2006.01706.x","type":"journal-article","created":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T14:25:17Z","timestamp":1158848717000},"page":"1485-1495","source":"Crossref","is-referenced-by-count":68,"title":["A double\u2010blind randomized controlled trial of antenatal mebendazole to reduce low birthweight in a hookworm\u2010endemic area of Peru"],"prefix":"10.1111","volume":"11","author":[{"given":"Ren\u00e9e","family":"Larocque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Casapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Gotuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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