{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:26:41Z","timestamp":1791851201339,"version":"4.3.4"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T00:00:00Z","timestamp":1165968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To determine the performance of rapid diagnostic tests for dengue and leptospirosis that rely on detecting antibodies that may not be produced when patients present for medical treatment.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We prospectively enrolled 723 patients with undifferentiated febrile illness presenting to rural hospitals in northern and northeastern Thailand over a 1\u2010year period. We evaluated rapid antibody detection diagnostic tests for dengue and leptospirosis on these patients.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Sensitivity of the tests was low at the acute visit (7.6\u201321.5%). Sensitivity at the convalescent visit ranged from 25.8% to 81.5% and was significantly higher than at the acute visit for all tests (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Low sensitivity of the rapid tests at presentation suggests that their utility in the acute phase of dengue and leptospirosis is limited.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2006.01752.x","type":"journal-article","created":{"date-parts":[[2010,8,11]],"date-time":"2010-08-11T22:11:18Z","timestamp":1281564678000},"page":"47-51","source":"Crossref","is-referenced-by-count":22,"title":["Rapid diagnostic tests for dengue and leptospirosis: antibody detection is insensitive at presentation"],"prefix":"10.1111","volume":"12","author":[{"given":"Adam L.","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott F.","family":"Dowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananda","family":"Nisalak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Mammen P.","family":"Mammen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wimol","family":"Petkanchanapong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara L.","family":"Fisk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.2.803-809.2003"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Case definitions for infectious conditions under public health surveillance. 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