{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:55:20Z","timestamp":1790268920969,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T00:00:00Z","timestamp":1169078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Adherence to antimalarial drug regimens is improved by simple dosing. If the fixed antimalarial drug combination artemether\u2013lumefantrine (AL) could be given once daily, this should improve adherence and thus effectiveness and lower the risk of selecting for resistance.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In an open randomized study, 43 patients with uncomplicated falciparum malaria were given equivalent doses of AL with 200\u2003ml flavoured milk either as the conventional twice\u2010daily regimen or as a single daily dose for 3\u2003days. The primary end point was a comparison of the areas under the plasma lumefantrine concentration\u2013time curves (AUC). Secondary end points were the day 42 polymerase chain reaction (PCR)\u2010adjusted cure rates and the tolerability profiles.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Lumefantrine pharmacokinetic profiles were obtained for 36 patients. The AUC<jats:sub>(0\u2192\u221e)<\/jats:sub> of the once\u2010daily regimen was 30% lower than that in the conventional regimen (<jats:italic>P<\/jats:italic>\u2003=\u20030.011) with a median (range) value of 306 (114\u20135781) <jats:italic>\u03bc<\/jats:italic>g\/ml\u2003h, compared with 432 (308\u2013992) <jats:italic>\u03bc<\/jats:italic>g\/ml\u2003h. There was no significant difference in the peak plasma concentrations reached. PCR\u2010adjusted cure rate estimates at day 42 of follow\u2010up were 94% (95% CI: 84\u2013100) in the six\u2010dose arm and 85% (70\u2013100) in the three\u2010dose arm (<jats:italic>P<\/jats:italic>\u2003=\u20030.3).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Artemether\u2013lumefantrine efficacy is reduced by once\u2010daily dosing, because absorption of lumefantrine is dose limited. At currently recommended doses, this antimalarial should be given twice daily in a 3\u2010day regimen, with food containing fat.<\/jats:p>","DOI":"10.1111\/j.1365-3156.2006.01785.x","type":"journal-article","created":{"date-parts":[[2010,8,11]],"date-time":"2010-08-11T22:10:55Z","timestamp":1281564655000},"page":"201-208","source":"Crossref","is-referenced-by-count":85,"title":["Pharmacokinetic study of artemether\u2013lumefantrine given once daily for the treatment of uncomplicated multidrug\u2010resistant falciparum malaria"],"prefix":"10.1111","volume":"12","author":[{"given":"Elizabeth A.","family":"Ashley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasia","family":"Stepniewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Lindeg\u00e5rdh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"McGready","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Annerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hutagalung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thida","family":"Singtoroj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilvary","family":"Hla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al","family":"Brockman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Proux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahser","family":"Wilahphaingern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratap","family":"Singhasivanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Nosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.06.022"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(00)90126-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.60.14"},{"key":"e_1_2_6_5_1","volume-title":"Basic and Clinical Biostatistics","author":"Dawson\u2010Saunders B","year":"1994"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00830.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.3.697-704.2000"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4269\/ajtmh.2004.71.525","article-title":"Adherence to a six\u2010dose regimen of artemether\u2013lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Uganda","volume":"71","author":"Fogg C","year":"2004","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-6411(00)00089-8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(96)90102-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02505-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9236(95)90037-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/503423"},{"issue":"1","key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1128\/AAC.42.1.135","article-title":"Randomized comparison of artemether\u2010benflumetol and artesunate\u2010mefloquine in treatment of multidrug\u2010resistant falciparum malaria","volume":"42","author":"Van Vugt M","year":"1998","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.60.936"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(00)90082-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(94)90471-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199937020-00002"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2004.01364.x"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3156.2006.01785.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3156.2006.01785.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T02:16:17Z","timestamp":1696904177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3156.2006.01785.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,18]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1365-3156.2006.01785.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3156.2006.01785.x","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,18]]}}}